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Hongke Liu Professor

Research Interests: 
1. Design, synthesis and full characterization of new organometallic complexes, the study of their coordination chemistry and the determination of relevant kinetic and thermodynamic parameters, determine their cytotoxicity both in vitro and in vivo. The p

2015-2019. Key International (Regional) Joint Research Program of National Nature Science Foundation of China(21420102002)

2015-2017. National Nature Science Foundation of China (21401105)

2012-2015. National Nature Science Foundation of China (21171095)

2009-2011. National Nature Science Foundation of China (20871069)

2008-2011. Programs issued by Jiangsu Province of China [NSF (BK2008428)

2014-2016. Six Talents Summit Project of Jiangsu Province

2014-2016. 333 Talents Project of Jiangsu Province

2013-2015. The Research Fund for the Doctoral Program of Higher Education of China (20123207110007)

Journal Articles

  1. Liu HK*, Sadler, P. J.*, Metal Complexes as DNA Intercalators, Acc. Chem. Res., 2011, 44, 349–359.
  2. Wang, J. T., Xu, L., Zhang, Z. Y., Sun, P. P., Fang, M., Liu HK*, Shape-controlled synthesis of a-Fe2O3 nanocrystals for efficient adsorptive removal of Congo red, RSC Adv., 2015, 5, 49696–49702.
  3. Wootton, C. A., Sanchez-Cano, C., Liu HK, Barrow, M. P., Sadler, P. J.* and O’Connor, P. B.,* Binding of an organo–osmium(II) anticancer complex to guanine and cytosine on DNA revealed by electron-based dissociations in high resolution Top–Down FT-ICR mass spectrometry, Dalton Trans., 2015, 44, 3624-3632.
  4. Wang, J. J. , Zhang J. , Jin, F. Y., Luo,Y.P., Wang, S. F., Zhang, Z. Y.,Wu, Y., Liu HK, Lu, Y. J. and Fang, M.*, Synthesis of an exceptional water-stable two-fold interpenetrated Zn(II)-paddlewheel metal-organic framework,CrystEngComm, 2015, 17, 5906–5910.
  5. Wang, S. F., Wang, J. J., Cheng, W. W.,Yang, X. W., Zhang, Z. Y., Xu, Y., Liu HK, Wu, Y. and Fang, M.*, A Zr metal–organic framework based on tetrakis-(4-carboxyphenyl) silane and factors affecting the hydrothermal stability of Zr-MOFs, Dalton Trans., 2015, 44, 8049–8061.
  6. Yang, Q., Luo, W., Wang, J. T.*, Liu HK*, Organometallic Ru (II) Complexes as anticancer agents, Science China, Chemistry, 2014,44, 437-447.
  7. Xu, L., Wang, J., Xu, Y., Zhang, Z., Lu, P., Fang, M., Li, S., Sun, P.,* and Liu HK*, A new strategy to construct metal–organic frameworks with ultrahigh chemical stability, CrystEngComm. , 2014, 16, 8656-59.
  8. Lu, P., Wu, Y. , Kang, H. , Wei, H.Y., Liu HK and Fang,M.*, What can pKa and NBO charges of the ligands tell us about the water and thermal stability of metalorganic frameworks, J. Mater. Chem. A, 2014, 2, 16250–16267.
  9. Zhang, Y., Luo, W. P., Liu, D. J., Xu, Y., Li, S. L., Li, J. F., Wu, Y., Zhou, Y. M., Fang, M.*, Liu HK*, Structures and photoluminescence properties of two cadmium(II) coordination polymers synthesized by flexible and rigid ligands, Inorg. Chim. Acta, 2013, 409, 512-517.
  10. Ma, C. H., Wang, J. T., Zhao, L., Shi, Y. Q., Luo, W. P., Yan, Y., Fang, M., Wang, X. J.*, Liu HK*, (M3L4+M2L4): a unique example of a co-crystal containing M3L4 and M2L4 metallocages, CrystEngComm., 2013, 15, 10311-10315.
  11. Ma, C., Wu, Y., Zhang, J., Xu, Y., Tu, B., Zhou, Y., Fang, M.,* Liu HK*, A 6-fold interpenetrated ThSi2 topological metal–organic framework from a nanosized tripodal aromatic acid, CrystEngComm. , 2012, 14, 5166-5169.(Top Ten)
  12. Sun, H., Xie, W., Lv, S., Xu, Y., Wu, Y., Zhou, Y., Ma, Z., Fang, M.,* Liu HK*, Two solvent and temperature dependent copper (II) compounds formed by a flexible ligand: syntheses, structures and SC–SC transformation, Dalton Trans., 2012, 41, 7590-95.
  13. Liu, H.-K., Burners-Price, Sue, Wang, F., Parkinson, Bella J., Xu, J., Sadler, P. J.*、Diversity in G-selective DNA binding modes for an organometallic ruthenium arene complex,Angew. Chem. Int. Ed. 2006,45, 8153-8156.
  14. Liu H. K., Wang, F., Parkinson, J., Bella J., and Sadler, P. J.*、Ruthenation of duplex and single-stranded d(CGGCCG) by organometallic anticancer complexes, Chem. Eur. J. 2006, 12, 6151-6165.
  15. Liu, H. K.*, Parkinson, J. A., Bella, J., Wang, F. Y., Sadler, P. J.*、DNA Penetrative DNA intercalation and G-base selectivity of an organometallic tetrahydroanthracene RuII anticancer complex,Chem. Sci., 2010, 2, 258-270.




  1. Liu, H.-K. Sadler, P. J. Interactions of Metallodrugs with DNA in NMR of Biomolecules: Towards Mechanistic Systems Biology,I. Bertini, K. McGreevy (Ed), Wiley VCH. Chapter 16, 283-295,2012.




Honors and Awards

2013. New medicine talent, The “Summit of the Six Top Talents” Program of Jiangsu Province

2011. Level 3 talent, 333 Talents Project of Jiangsu Province


Academic Title


Vice Director of Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, Jiangsu Key Laboratory of Biofunctional Materials