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Faculty

Huihui Li Associate Professor

Academic Area: 
Bioanalytical Chemistry, Chemical Biology
Research Interests: 
Noncovalent interactions of DNA and small molecules, Structural analysis of human disease-related DNA, Biological Mass Spectrometry, Capillary Electrophoresis-Mass Spectrometry
Bio: 

Research Projects

2020-2023, Study on the interaction between aptamers and the apoptosis-related protein based on capillary electrophoresis-mass spectrometry (National Nature Science Foundation of China).

2015-2017, Study of the leading compounds in natural anti-cancer drug design targeted oncogene quadruplex nucleic acids (Natural Science Foundation of the Higher Education Institutions of Jiangsu Province).

2015-2016, The characteristices, interaction and the regulation mechanism of biological functions of c-myb oncogene G-quadruplex and i-motif DNA (Beijing National Laboratory for Molecular Sciences).

2014-2016, The characteristices, interaction and the regulation mechanism of biological functions of c-myb oncogene G-quadruplex and i-motif DNA (State Key Laboratory of Analytical Chemistry for Life Science).

2010-2012, Studies on the mechanism of interaction between environmental organic pollutants and human tumors related DNA (National Nature Science Foundation of China).

2009-2011, Study of the mechanism of interactions between environmental organic pollutants and human tumor gene DNA (Natural Science Foundation of the Higher Education Institutions of Jiangsu Province).

 

Journal Articles

  1. Pengfei Yang, Xinyi Wang, Zhenggui Gu, Huihui Li*, David D. Y. Chen*, Xiaodi Yang*, Evaluation of the binding of natural products with thrombin binding aptamer G-quadruplex using electrospray ionization mass spectrometry and spectroscopic methods. Talanta, 2019, 200, 424-431.
  2. Hengqing Fu, Cheng Qian, Wenjun Tong, Huihui Li*, David D.Y. Chen* Mass spectrometry and affinity capillary electrophoresis for characterization of host-guest interactions. J. Chromatogr. A 2019, 1589, 182-190.
  3. Hengqing Fu, Pengfei Yang, Jinhui Hai, Huihui Li*, Utilization of circular dichroism and electrospray ionization mass spectrometry to understand the formation and conversion of G-quadruplex DNA at the human c-myb proto-oncogene. Spectrochim. Acta A 2018, 203, 70-76. 
  4. Cheng Qian#, Su Wang#, Hengqing Fu, Robin F. B. Turner, Huihui Li*, David D. Y. Chen*, Pressure-assisted capillary electrophoresis frontal analysis for faster binding constant determination. Electrophoresis 2018, 39(14), 1786-1793.
  5. Cheng Qian#, Hengqing Fu#, Kevin A. Kovalchik, Huihui Li*, and David Da Yong Chen*, Specific binding constant and stoichiometry determination in free solution by mass spectrometry and capillary electrophoresis frontal analysis. Anal. Chem. 2017, 89(17), 9483-9490.
  6. Shanshan Fan#, Jun Zhu#, Lixuan Ren, Man Wang, Wentao Bi*, Huihui Li, Xiaohua Huang, David Chen*, Co-solvent enhanced adsorption with magnetic velvet-like carbon nitride for high efficiency solid phase extraction. Anal. Chim. Acta 2017, 960, 63-71. 
  7. Huihui Li*, Jinhui Hai, Jiang Zhou, Gu Yuan*, The formation and characteristics of the i-motif structure within the promoter of the c-myb proto-oncogene. J. Photoch. Photobio. B 2016, 162, 625-632.
  8. Huihui Li*, Jinhui Hai, Jiang Zhou, Gu Yuan*, Exploration of binding affinity and selectivity of brucine with G-quadruplex in the c-myb proto-oncogene by electrospray ionization mass spectrometry. Rapid Commun. Mass Spectrom. 2016, 30(3), 407-414.
  9. Shiwei Zhang, Huihui Li, Jiang Zhou*, XIaodi Yang, Formation and properties of G-quadruplex formed from Kras promoter by ESI-MS. J. Chinese Mass Spectrom. Soc. 2015, 36 (6), 521-528.
  10. Huihui Li, Shiwei Zhang, Jiang Zhou*, Xiaodi Yang*, Specific binding of human telomeric G-quadruplex by Homobarringtonie, an alkaloid from traditional Chinese medicine. Int. J Mass Spectrom. 2015, 379, 157-164.
  11. Jia Lu, Xiaoyang Bu, Jing Wang, Huihui Li*, Xiaodi Yang*, Spectrometric Study on Interactions between Organochlorine Pesticides and DNA. Chinese J. Anal. Chem. 2014,42(4), 482-488.
  12. Li Li, Jia Lu,Wenshu Zhou, Huihui Li*, Xiaodi Yang*, Studies on the Interaction Mechanism of Aminopyrene Derivatives with Human Tumor-Related DNA. J. Photoch. Photobio. B, 2013, 123, 32-40.
  13. Huihui Li, Xiaoyang Bu, Jia Lu, Chongzheng Xu, Xianlong Wang, Xiaodi Yang*, Interaction Study of Ciprofloxacin with Human Telomeric DNA by Spectroscopy and Molecular Docking. Spectrochim. Acta A, 2013, 107, 227-234.
  14. Li Li, Yongzheng Tang, Huihui Li, Xujie Yang, Tianhong Lu, Xiaodi Yang*, Interactions of Nicotinamides Adenine dinucleotide phosphate with nano-boehmite and nano-corundum. Chinese J. Inorg. Chem. 2013, 29(1), 111-122.
  15. Na Li, Yinghong Xiao, Chongzheng Xu, Xiaodi Yang*, Huihui Li*, Facile Preparation of polyaniline nanoparticles via Electrodeposition for Supercapacitors, Int. J. Electrochem. Sci., 2013, 8(1), 1181-1188.
  16. Yuanyuan Jiang, Kun Wang, Chongzheng Xu, Xiaodi Yang*, Huihui Li*, Application of alizarin/graphene-chitosan modified electrode on detection of human telomere DNA. Chinese J. Anal. Chem. 2013, 41(4), 481-487.
  17. Li Li, Jia Lu, Chongzheng Xu, Huihui Li* and Xiaodi Yang*, Studies on the Interaction Mechanism of Pyrene Derivatives with Human Tumor-Related DNA. Molecules 2012, 17(12), 14159-14173.
  18. Yuanyuan Jiang, Ye Yuan, Kun Wang, Huihui Li*, Chongzheng Xu, Xiaodi Yang*, Spectroscopic and electrochemical studies on the binding of pyrocatechol violet with telomere DNA and its application. Int. J. Electrochem. Sci. 2012, 7, 10933-10951.
  19. Li Li, Jia Lu, Xuemei Liu, Huihui Li*, Xiaodi Yang*, Study on the interaction of Tirclosan with Human Tumor Related DNA by Spectroscopic methods. J. Instrum. Anal. 2012, 31(8),951-956.
  20. Yongxin Zhao, Li Li, Kun Wang, Tianhong Lu, Xiaodi Yang*, Huihui Li*, Application of grapheme-chitosan modified electrode for the detection of pentachlorophenol in environmental water. Chinese J. Appl. Chem. 2012, 29(10), 1206-1211.
  21. Nannan Zhang, Yongzheng Tang, Fei Ma, Huihui Li, Tianhong Lu, Xiaodi Yang*, Electrochemical studies on effects of glutathione reductase activity by Al3+ and Nano-Al13. Chinese J. Anal. Chem. 2012, 40(4), 584-588.
  22. Xiaodi Yang, Ling Cai, Yu Peng, Huihui Li, Rong Fu Chen and Ren Fang Shen*, Effects of Al(III) and nano-Al13 species on malate dehydrogenase activity. Sensors, 2011, 11(6), 5740-5753.
  23. Gu Yuan*, Qiang Zhang, Jiang Zhou and Huihui Li, Mass spectrometry of G-quadruplex DNA: Formation, recognition, property, conversion, and conformation. Mass Spectrom. Rev. 2011, 30(3), 1121-1142.
  24. Xiaoyang Bu, Ming Wu, Jiahong Zhou, Xiaodi Yang, Tianhong Lu, Huihui Li*, Spectrometric study on the interactions between organic pesticide pollutants and DNA. Chinese J. Appl. Chem. 2011, 28(4), 458-463.

 

Books

2019, Huihui Li, Mass Spectroscopic Study of G-Quadruplex. In: Danzhou Yang, Clement Lin (eds) G-Quadruplex Nucleic Acids. Methods in Molecular Biology, vol 2035. Humana, New York, NY.

 

2014, Kaian Yao, Dengshan Zhao, Jiming Wang, Jingping Wang, Huihui Li, Instrumental Analysis, Nanjing University Press, Nanjing.

 

2013, Xiaodi Yang, Huihui Li in Robert H. Kretsinger, Vladimir N. Uversky, Eugene A. Permyakov. Encyclopedia of Metalloproteins, Springer, New York.

 

Patents

The nano-AlOOH encapsulated sodium percarbonate degradation agent for pyrethroid pesticides, and its preparation method and applications. ZL200910231750.9 2012, 1/4.

 

Honors and Awards

China Association for Instrumental Analysis (CAIA) Award, 2007.

China Association for Instrumental Analysis (CAIA) Award, 2008.

Outstanding graduates, Peking University, 2008.

Junior Faculty Teaching Award, Nanjing Normal University, 2011.

"Project Blue" outstanding Junior Faculty training object, Nanjing Normal University, 2012.

Undergraduate Teaching Award, Nanjing Normal University, 2015.

Graduate Teaching Award, Nanjing Normal University, 2015.

 

Contact

Tel: +86 25 85891496  

Fax: +86 25 85891707

E-mail: huihuili@njnu.edu.cn