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Faculty

Liang-An Chen Professor

Bio: 

Educational Background

Postdoc. Department of Chemistry, Indiana University, 2018-2019 (with Kevin Brown)

Postdoc. Department of Chemistry, Columbia University, 2015-2018 (with James Leighton)

Ph.D. Organic Chemistry, Xiamen University, 2011-2014 (with Eric Meggers)

M.S. Organic Chemistry, Xiamen University (Pei-Qiang Huang and Aie Wang, 2008-2011)

B.S. Chemistry, Fuyang Normal University (2004-2008)

 

Research Interests

Focus on organic synthesis methodologies with metal catalysis, Development of step-economy, and practical methods and strategies for biologically active natural product and drug synthesis.

  1. Asymmetric Catalysis; 2) Transition metal-catalysis; 3) Natural Products total Synthesis

 

Selected Publications

  1. Dengkai Lin, Yongzhi Chen, Zhan Dong, Pan Pei, Haiting Ji, Lanzhu Tai, Liang-An Chen*, “A General and Modular Access to Enantioenriched α‑Trifluoromethyl Ketones via Nickel-Catalyzed Reductive Cross-Coupling,” ChemRxiv 2022, DOI: 10.26434/chemrxiv-2022-ghw8h.
  2. Mengfu Dai, Zhimin Sun, Liang-An Chen*, “Palladium-Catalyzed Regiodivergent Synthesis of 1,3-Dienyl and Allyl Esters from Propargyl Esters,” Angew. Chem. Int. Ed. 2022, DOI: 10.1002/anie.202203835.
  3. L.-A Chen, A. R. Lear, P. Gao, M. K. Brown*, “Nickel-Catalyzed Arylboration of Alkenylarenes: Synthesis of Boron-Substituted Quaternary Carbons and Regiodivergent Reactions”. Angew. Chem. Int. Ed. 2019, 58, 10956-10960
  4. P. Gao#, L.-A Chen#, M. K. Brown*, “Nickel-Catalyzed Stereoselective Diarylation of Alkenylarenes,” J. Am. Chem. Soc. 2018, 140, 10653-10657.,(#equal contribution, highlighted by Synfacts and X-mol, most read articles in August 2018)
  5. L.-A. Chen, M. A. Ashley, J. L. Leighton*, “Evolution of an Efficient and Scalable Nine-Step (Longest Linear Sequence) Synthesis of Zincophorin Methyl Ester”, J. Am. Chem. Soc. 2017, 139, 4568-4573. (Highlighted by Chemistry World and X-mol)
  6. L.-A. Chen, W. Xu, B. Huang, J. Ma, L. Wang, J. Xi, K. Harms, L. Gong*, E. Meggers*, “Asymmetric Catalysis with an Inert Chiral-at-Metal Iridium Complex”, J. Am. Chem. Soc. 2013, 135, 10598-10601. (Cover Paper, highlighted by JACS Spotlights and Synfacts)
  7. L.-A. Chen, X. Tang, J. Xi, W. Xu, L. Gong*, E. Meggers*, “Chiral-at-Metal Octahedral Iridium Catalyst for Asymmetric Construction of an All-Carbon Quaternary Stereocenter”, Angew. Chem. Int. Ed. 2013, 125, 14271-14275. (Highlighted by Synfacts)

 

Contact

Email：lachen@njnu.edu.cn; lachen2119@gmail.com

Google Scholar: scholar.google.com/citations?hl=en&user=wAqtvMo

ORCID: https://orcid.org/0000-0003-3423-3390