
Educational Background
03/2018-05/2019, Postdoc. Department of Chemistry, Indiana University (with Prof. Kevin Brown)
01/2015-03/2018, Postdoc. Department of Chemistry, Columbia University (with Prof. James Leighton)
09/2011-12/2014, Ph.D. Organic Chemistry, Xiamen University (with Prof. Eric Meggers)
09/2008-09/2011, M.S. Organic Chemistry, Xiamen University ( with Prof. Pei-Qiang Huang and Aie Wang)
09/2004-07/2008, B.S. Chemistry, Fuyang Normal University
Research Interests
Asymmetric Catalysis, Transition Metal-Catalysis, Natural Product Total Synthesis. Focus on step-economy and practical Fragment-Oriented Synthesis (FOS), Development of new methods and strategies for biologically active natural product and drug synthesis.
Selected Publications
- L.-A. Chen, A. R. Lear, P. Gao and M. K. Brown*, “Nickel-Catalyzed Arylboration of Alkenylarenes: Synthesis of Boron-Substituted Quaternary Carbons and Regiodivergent Reactions”. Angew. Chem. Int. Ed. 2019, 58, 10956-10960
- P. Gao#, L.-A. Chen# and M. K. Brown*, “Nickel-Catalyzed Stereoselective Diarylation of Alkenylarenes,” J. Am. Chem. Soc. 2018, 140, 10653-10657. (#equal contribution, highlighted by Synfacts and X-mol, most read articles in August 2018)
- L.-A. Chen, M. A. Ashley and J. L. Leighton*, “Evolution of an Efficient and Scalable Nine-Step (Longest Linear Sequence) Synthesis of Zincophorin Methyl Ester”, J. Am. Chem. Soc. 2017, 139, 4568-4573. (Highlighted by Chemistry World and X-mol)
- L.-A. Chen, W. Xu, B. Huang, J. Ma, L. Wang, J. Xi, K. Harms, L. Gong* and E. Meggers*, “Asymmetric Catalysis with an Inert Chiral-at-Metal Iridium Complex”, J. Am. Chem. Soc. 2013, 135, 10598-10601. (Cover Paper, highlighted by JACS Spotlights and Synfacts)
- L.-A. Chen, X. Tang, J. Xi, W. Xu, L. Gong* and E. Meggers*, “Chiral-at-Metal Octahedral Iridium Catalyst for Asymmetric Construction of an All-Carbon Quaternary Stereocenter”, Angew. Chem. Int. Ed. 2013, 125, 14271-14275. (Highlighted by Synfacts)
- H. Huo, X. Shen, C. Wang, L. Zhang, P. Röse, L.-A. Chen, K. Harms, M. Marsch, G. Hilt and E. Meggers*, “Asymmetric Photoredox Transition Metal Catalysis Activated by Visible Light”, Nature, 2014, 515, 100-103. (Highlighted by Nature, C&EN News and Synfacts)
Honors and Awards
- Outstanding Research Achievement Award, Xiamen University (2014)
- Graduate National Scholarship, Ministry of Education of China (2013)
- Zhengxin Scholarship, Xiamen University (2012)
- Kingdomway Scholarship, Xiamen University (2011)
- Graduate with Excellent Character and Study of Anhui Province (2008)
Contact
Email:lachen@njnu.edu.cn; lachen2119@gmail.com
Google Scholar: scholar.google.com/citations?hl=en&user=wAqtvMoAAAAJ