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Liang-An Chen Professor


Educational Background

03/2018-05/2019, Postdoc. Department of Chemistry, Indiana University (with Prof. Kevin Brown)

01/2015-03/2018, Postdoc. Department of Chemistry, Columbia University (with Prof. James Leighton)

09/2011-12/2014, Ph.D. Organic Chemistry, Xiamen University (with Prof. Eric Meggers)

09/2008-09/2011, M.S. Organic Chemistry, Xiamen University ( with Prof. Pei-Qiang Huang and Aie Wang)

09/2004-07/2008, B.S. Chemistry, Fuyang Normal University


Research Interests

Asymmetric Catalysis, Transition Metal-Catalysis, Natural Product Total Synthesis. Focus on step-economy and practical Fragment-Oriented Synthesis (FOS), Development of new methods and strategies for biologically active natural product and drug synthesis.


Selected  Publications

  1. L.-A. Chen, A. R. Lear, P. Gao and M. K. Brown*, “Nickel-Catalyzed Arylboration of Alkenylarenes: Synthesis of Boron-Substituted Quaternary Carbons and Regiodivergent Reactions”. Angew. Chem. Int. Ed. 2019, 58, 10956-10960
  2. P. Gao#, L.-A. Chen# and M. K. Brown*, “Nickel-Catalyzed Stereoselective Diarylation of Alkenylarenes,” J. Am. Chem. Soc. 2018, 140, 10653-10657. (#equal contribution, highlighted by Synfacts and X-mol, most read articles in August 2018)
  3. L.-A. Chen, M. A. Ashley and J. L. Leighton*, “Evolution of an Efficient and Scalable Nine-Step (Longest Linear Sequence) Synthesis of Zincophorin Methyl Ester”, J. Am. Chem. Soc. 2017, 139, 4568-4573. (Highlighted by Chemistry World and X-mol)
  4. L.-A. Chen, W. Xu, B. Huang, J. Ma, L. Wang, J. Xi, K. Harms, L. Gong* and E. Meggers*, “Asymmetric Catalysis with an Inert Chiral-at-Metal Iridium Complex”, J. Am. Chem. Soc. 2013, 135, 10598-10601. (Cover Paper, highlighted by JACS Spotlights and Synfacts)
  5. L.-A. Chen, X. Tang, J. Xi, W. Xu, L. Gong* and E. Meggers*, “Chiral-at-Metal Octahedral Iridium Catalyst for Asymmetric Construction of an All-Carbon Quaternary Stereocenter”, Angew. Chem. Int. Ed. 2013, 125, 14271-14275. (Highlighted by Synfacts)
  6. H. Huo, X. Shen, C. Wang, L. Zhang, P. Röse, L.-A. Chen, K. Harms, M. Marsch, G. Hilt and E. Meggers*, “Asymmetric Photoredox Transition Metal Catalysis Activated by Visible Light”, Nature, 2014, 515, 100-103. (Highlighted by Nature, C&EN News and Synfacts)

Honors and Awards

  1. Outstanding Research Achievement Award, Xiamen University (2014)
  2. Graduate National Scholarship, Ministry of Education of China (2013)
  3. Zhengxin Scholarship, Xiamen University (2012)
  4. Kingdomway Scholarship, Xiamen University (2011)
  5. Graduate with Excellent Character and Study of Anhui Province (2008)


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