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Academic report: Iron chelation inhibition of mTORC1 signaling in cancer cells

   Prof. Huang Shile from Louisiana State University Feist-Weiller Cancer Center visited NNU School of Life Sciences for scientific knowledge exchange on June 1, 2016 at the invitation of School of Life Sciences and Jiangsu Key Laboratory for Molecular and Medical Biotechnology. He delivered an academic report titled “Iron chelation inhibition of mTORC1 signaling in cancer cells” at the round meeting room on the 3rd floor of School of Life Sciences at 10:00 a.m. The report was chaired by Prof. Chen Long from the Institute of Biochemistry and Biological Products, and was attended by teachers, graduate students and undergraduates whose work were related to physiology, biochemistry and cell, of School of Life Sciences.
   In the seminar, Prof. Huang detailed the latest research results of his laboratory, namely, the discovery of iron chelating agents in inhibiting phosphorylation of downstream signal molecules S6K1 and 4E-BP1 in mTORC1 pathways of cancer cells, and clarified the key role of the pathway activation of AMPK and HIF-Bnip3, the interaction between protein mTOR and protein PML and the translocation in cells in iron chelation inhibiting mTORC1. Prof. Huang’s explained how the iron chelating agent play an anti-tumor effect through the inhibition of the mTORC1 signaling pathway, and the molecular mechanism, which provided a new idea for the development of novel anti-cancer drugs. At the end of the seminar, Prof. Huang answered questions and exchanged ideas with the faculty and students on the related issues. The seminar received a warm applause. In the afternoon, Prof. Huang listened to Prof. Chen Long’s work report on lectures to laboratory post doctoral, doctoral and master students, and offered a thorough review and guidance for research design, implementation plan and related technical details.