On November 13, 2017, Dr. Tingting Zhang, at the invitation of Prof. Yuqing Chen, came to the School of Life Sciences for an academic exchange. Dr. Zhang gave a talk entitled" Step-wise formation of Germinal Center B cells is completed by a requisite Tfh disengagement " on nov 13.
Dr. Zhang's work focuses on the issues of how CD40 signaling can be required for B cell commitment to the GC lineage while also inhibiting its formation. In her work, she found that GC B cell differentiation is a two-stage process;(1) a T-cell contact and CD40-dependent phase that generates RelB+ IRF4+ BCL6int GC precursors and (2) a phase immediately following that is prevented by further CD40 signaling but nevertheless needed to complete their transition to BCL6hi GC B cells. The research was published in the journal of eLIFE. At the end of the presentation, Dr. Zhang introduced the application of Two-photon laser confocal microscope to the teachers and students present. The meeting ended in a massive round of applause