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Academic Report: Step-wise formation of Germinal Center B cells was completed by a requisite Tfh disengagement

On November 13, 2017, Dr. Tingting Zhang, at the invitation of Prof. Yuqing Chen, came to the School of Life Sciences for an academic exchange. Dr. Zhang gave a talk entitled" Step-wise formation of Germinal Center B cells is completed by a requisite Tfh disengagement " on nov 13.

Dr. Zhang's work focuses on the issues of how  CD40 signaling can be required for B cell commitment to the GC lineage while also inhibiting its formation. In her work, she found that GC B cell differentiation is a two-stage process;(1) a T-cell contact and CD40-dependent phase that generates RelB+ IRF4+ BCL6int GC precursors and (2) a phase immediately following that is prevented by further CD40 signaling but nevertheless needed to complete their transition to BCL6hi GC B cells. The research was published in the journal of eLIFE. At the end of the presentation, Dr. Zhang introduced the application of Two-photon laser confocal microscope to the teachers and students present. The  meeting ended in a massive round of applause