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Chang Liu Professor

Research Interests: 
Molecular pathogenesis of metabolic syndromes including type 2 diabetes, fatty liver, atherosclerosis and insulin resistance, especially the integration of circadian clock, transcriptional coactivators, and energy metabolism regulation.

Educational Background

PhD, Pathophysiology, Institute of Molecular Medicine, Nanjing University (2005)

BS, Biochemistry, Institute of Molecular Medicine, Nanjing University , (1995)

Research Projects

  • As a PI, I am in charge of 8 grants from the National Basic Research Program of China (973 Program; 2012CB947600, 2013CB911600)
  • The National Natural Science Foundation of China (NSF; 31171137, 31422028, 31271261)
  • Ten Thousand Talents Program, programs issued by Jiangsu Province of China [NSF (BK20140041)
  • Six Talents Summit Project, and 333 Talents Project (BRA2015323)]
  • The Key Project of Chinese Ministry of Education (211062)
  • The Research Fund for the Doctoral Program of Higher Education of China (20103207110007)
  • The Fok Ying Tong Education Foundation (121022)
  • The Major Program of Educational Commission of Jiangsu Province (09KJA180004)
  • The Collaborative Innovation Center for Cardiovascular Disease Translational Medicine (Nanjing Medical University) and the Priority Academic Program Development of Jiangsu Higher Education Institutions.

Journal Articles

  • Zhang W,Wang P,Chen S,Zhang Z,Liang T*,Liu C*,(2016) Rhythmic Expression of miR-27 Targets the Clock Gene Bmal1 through Post-transcriptional Rgulation in the Mouse Liver,The FASEB Journal, doi:10.1096/fj.201500120fj.201500120 (IF=5.043)
  • Ge X, Chen S, Liu M, Liang T, Liu C*, (2015) Evodiamine Attenuates PDGF-BB-induced Migration of Rat Vascular Smooth Muscle Cells through Activating PPARγ,International Journal of Molecular Sciences,16(12):28180-28193 (IF=2.862)
  • Wang D, Chen S & Liu C.* (2015) Maternal obesity disrupts circadian rhythms of clock and metabolic genes in the offspring heart and liver. Chronobiology International, 32,1-12 (IF=4.35) 
  • Zhang J,Zhang J,Zhao C,Shen R,Guo X,Li C,Ling X *,Liu C *,(2014) Analysis of Transcription Factor Stk40 Expression and Function during Mouse Pre-implantation Embryonic Development, Molecular Medicine Reports, 9(2):535-540 (IF=1.544)
  • Zhang YY, Meng C, Zhang XM, Yuan CH, Wen MD, Chen Z, Dong DC, Gao YH, Liu C & Zhang Z.* (2015) Ophiopogonin D attenuates Doxorubicin-induced autophagic cell death by relieving mitochondrial damage in vitro and in vivo. Journal of Pharmacological and Experimental Therapeutics, 352, 166-174. (IF=3.891)
  • Liang T, Yang C, Li P, Liu C & Guo L.* (2014) Genetic analysis of loop sequences in the let-7 gene family reveal a relationship between loop evolution and multiple isomiRs. PLoS One, 9, e113042. (IF=4.41)
  • Chen S, Qian J, Shi X, Gao T, Liang T & Liu C.* (2014) Control of hepatic gluconeogenesis by the promyelocytic leukemia zinc finger protein. Molecular Endocrinology, 28, 1987-1998. (IF=4.54)
  • Liang T, Yu J, Liu C & Guo L.* (2014) An exploration of evolution, maturation, expression and function relationships in mir-23-27-24 cluster. PLoS One, 9, e106223. (IF=4.41)
  • Chen S, Zhang W, Tang C, Tang X, Liu L & Liu C.* (2014) Vanin-1 is a key activator for hepatic gluconeogenesis. Diabetes, 63, 2073-2085. (IF=7.90)
  • Chen S, Ding Y, Zhang Z, Wang H & Liu C.* (2014) Hyperlipidemia impairs the circadian clock and physiological homeostasis of vascular smooth muscle cells via the suppression of Smarcd1. Journal of Pathology, 233, 159-169 (cover story). (IF=7.59)
  • Qian J, Chen S, Huang Y, Shi X & Liu C.* (2013) PGC-1α regulates hepatic hepcidin expression and iron homeostasis in response to inflammation. Molecular Endocrinology, 27, 683-692. (IF=4.54)
  • Liang T*, Liu C & Ye Z. (2013) Deep sequencing of small RNA repertoires in mice reveals metabolic disorders-associated hepatic miRNAs. PLoS One, 8, e80774. (IF=4.41)
  • Xu Y, Diao Y, Qi S, Pan X, Wang Q, Xin Y, Cao X, Ruan J, Zhao Z, Luo L*, Liu C*, Yin Z.* (2013) Phosphorylated Hsp27 activates ATM-dependent p53 signaling and mediates the resistance of MCF-7 cells to doxorubicin-induced apoptosis. Cellular Signalling, 25, 1176-1185. (IF=4.06)
  • Wang Z, Zhang X, Chen S, Wang D, Wu J, Liang T & Liu C.* (2013) Lithium chloride inhibits vascular smooth muscle cell proliferation and migration and alleviates injury-induced neointimal hyperplasia via induction of PGC-1α. PLoS One, 8, e55471. (IF=4.41)
  • Fu J, Chen D, Zhao B, Zhao Z, Zhou J, Xu Y, Xin Y, Liu C, Luo L & Yin Z.* (2012) Luteolin induces carcinoma cell apoptosis through binding Hsp90 to suppress constitutive activation of STAT3. PLoS One, 7, e49194. (IF=4.41)
  • Liang T, Guo L & Liu C.* (2012) Genome-wide analysis of mir-548 gene family reveals evolutionary and functional implications. Journal of Biomedicine and Biotechnology 2012, 679563. (IF=2.44)
  • Wang B, Chen N, Wei Y, Li J, Sun L, Wu J, Huang Q, Liu C, Fan C & Song H.* (2012) Akt signaling-associated metabolic effects of dietary gold nanoparticles in Drosophila. Scientific Reports 2, 563-569. (IF=2.93)
  • Yi N, Chen S, Ma A, Chen P, Yao B, Liang T & Liu C.* (2012) Tunicamycin inhibits PDGF-BB-induced proliferation and migration of vascular smooth muscle cells through induction of HO-1. Anatomical Record (Hoboken), 295, 1462-1472. (IF=1.47)
  • Chen S, Ding Y, Tao W, Zhang W, Liang T & Liu C.* (2012) Naringenin inhibits TNF-α induced VSMC proliferation and migration via induction of HO-1. Food and Chemical Toxicology, 50, 3025-3031. (IF=3.00)
  • Tao W, Chen S, Shi G, Guo J, Xu Y & Liu C.* (2011) SWItch/sucrose nonfermentable (SWI/SNF) complex subunit BAF60a integrates hepatic circadian clock and energy metabolism. Hepatology, 54, 1410-1420. (IF=11.67)
  • Yao X, Zhu F, Zhao Z, Liu C, Luo L & Yin Z.* (2011) Arctigenin enhances chemosensitivity of cancer cells to cisplatin through inhibition of the STAT3 signaling pathway. Journal of Cell Biochemistry, 112, 2837-2849. (IF=2.87)
  • Liu C* & Lin JD.* (2011) PGC-1 coactivators in the control of energy metabolism. Acta Biochimica et Biophysica Sinica, 43, 248-257. (IF=1.55)
  • Jiang F, Qian J, Chen S, Zhang W & Liu C.* (2011) Ligustrazine improves atherosclerosis in rat via attenuation of oxidative stress. Pharmaceutical Biology, 49, 856-863. (IF=0.64)
  • Liu C.* (2010) Response to “HO-1 attenuates hypertension-induced Inflammation/Oxidative Stress. Support from Bartter's/Gitelman's patients”. American Journal of Hypertension, 23, 937. (IF=3.13)
  • Yu X, Tao W, Jiang F, Li C, Lin J & Liu C.* (2010) Celastrol attenuates hypertension-induced inflammation and oxidative stress in vascular smooth muscle cells via induction of heme oxygenase-1. American Journal of Hypertension, 23, 895-903. (IF=3.13)
  • Xu Y, Chen J, Yu X, Tao W, Jiang F, Yin Z & Liu C.* (2010) Protective effects of chlorogenic acid on acute hepatotoxicity induced by lipopolysaccharide in mice. Inflammation Research, 59, 871-877. (IF=2.00)
  • Qian J, Jiang F, Wang B, Yu Y, Zhang X, Yin Z & Liu C.* (2010) Ophiopogonin D prevents H2O2-induced injury in primary human umbilical vein endothelial cells. Journal of Ethnopharmacology, 128, 438-445. (IF=2.47)
  • Jiang X, Zhang Y, Hou D, Zhu L, Xu W, Ding L, Qi X, Sun G, Liu C, Zhang J, Zen K, Xiang Y, Zhang CY.* (2010) 17beta-Estradiol inhibits oleic acid-induced rat VSMC Proliferation and migration by restoring PGC-1 expression. Molecular and Cellular Endocrinology, 315, 74–80. (IF=4.19)
  • Li S, Arning E, Liu C, Vitvitsky V, Hernandez C, Banerjee R, Bottiglieri T & Lin JD.* (2009) Regulation of homocysteine homeostasis through the transcriptional coactivator PGC-1α. AJP-Endocrinology and Metabolism, 296, E543-548. (IF=4.69)
  • Li S, Liu C, Li N, Hao T, Han T, Hill D, Vidal M & Lin JD.* (2008) Genome-wide Coactivation Analysis Identifies BAF60a as a Regulator of Lipid Metabolism Through PGC-1. Cell Metabolism, 8, 105-17. (IF=18.21)
  • Lin JD*, Liu C, Li S. (2008) Integration of energy metabolism and the mammalian clock. Cell Cycle, 7, 453-7. (IF=5.00)
  • Liu C, Li S, Liu T, Borjigin J & Lin JD.* (2007) Transcriptional coactivator PGC-1 integrates the mammalian clock and energy metabolism. Nature, 447, 477-81. (IF=36.10)
  • Zhang Y, Ba Y, Liu C, Sun G, Ding L, Gao S, Hao J, Yu Z, Zhang J, Zen K, Tong Z, Xiang Y & Zhang CY.* (2007) PGC-1 induces apoptosis in human epithelial ovarian cancer cells through a PPAR-dependent pathway. Cell Research, 17, 363-73. (IF=9.42)
  • Zhang Y, Liu C, Zhu L, Jiang X, Chen X, Qi X, Liang X, Jin S, Zhang P, Li Q, Wang D, Liu X, Zeng K, Zhang J, Xiang Y & Zhang CY.* (2007) PGC-1 Inhibits Oleic Acid Induced Proliferation and Migration of Rat Vascular Smooth Muscle Cells. PLoS One, 2, e1137. (Co-first author, IF=4.41)
  • Zhang P, Liu C, Zhang C, Zhang Y, Shen P, Zhang J & Zhang CY.* (2005) Free fatty acids increase PGC-1 expression in isolated rat islets. FEBS Letters, 579, 1446-1452. (Co-first author, IF=3.54)

Honors and Awards

Outstanding Youth Foundation of NCSF

Ten Thousand Talents Program

Distinguished Young Scholars of Jiangsu Province

Academic Title

Professor of Cell Biology and Pathophysiology, PhD supervisor, 

Director of Jiangsu Key Laboratory for Molecular and Medical Biotechnology 

Member of the Chinese Society of Cell Biology and Fellow of the Medical Cell Biology Branch

Member of the vice chairman of Jiangsu Society for Cell and Developmental Biology

Member of the editorial board of <American Journal of Cardiovascular Disease> and <World Journal of Hypertension>


Address: Colloge of Life Sciences, Nanjing Normal University, Nanjing, P.R.China 210046

Tel: 025-85891870