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Faculty

Feiyan Pan Lecturer

Research Interests: 
  • DNA repair and epigenetic regulation
  • Cell division and tumor proliferation
Bio: 

Educational Background

PhD, Cell biology, Nanjing Normal University (2010)

MS, Cell biology, Nanjing Normal University (2005)

BA, Life Science, Nanjing Normal University (2000)

Research Projects

  • Egr-1 promote hepatocellular carcinoma cell scattering through regulating PRL-3 transcription and posttranslational modification. National Natural Science Foundation of China. Grant No: 30800574 1/2009– 12/2011
  • HGF/Egr-1/PRL-3/Ezrin/E-cadherin signalling pathway affect HepG2 cell scattering. Natural Science Foundation of Jiangsu Province. Grant No: BK2008432 1/2009– 12/2011
  • Cell model. Natural Science Foundation of University. 07KJD180103 9/2007– 12/2009 

Journal  Articles

  • Zhou T, Pan F, Cao Y, Han Y, Zhao J, Sun H, Zhou X, Wu X, He L, Hu Z, Chen H, Shen B, Guo Z, R152C DNA Pol β mutation impairs base excision repair and induces cellular transformation, Oncotarget, 2016, 7(6):6902-6915.
  • Pan F, Zhao J, Zhou T, Kuang Z,  Dai H, Wu H, Sun H, Zhou X,  Wu X, Hu Z, He L, Shen B, Guo Z, Mutation of DNA Polymerase β R137Q Results in Retarded Embryo Development Due to Impaired DNA Base Excision Repair in Mice, Scientific Reports, 2016, 6:28614
  • H Sun, L He, H Wu, F Pan, X Wu, J Zhao, Z Hu, C Sekhar, H Li, L Zheng, H Chen, BH Shen and Z Guo, The FEN1 L209P mutation interferes with long-patch base excision repair and induces cellular transformation, Oncogene, 2016, 1-14
  • Na Xu, Shan Guan, Zhong Chen, Yang Yu, Jun Xie, Fei-Yan Pan, Ning-Wei Zhao, Li Liu, Zhong-Zhou Yang, Xiang Gao, Biao Xu, Chao-Jun Li, The alteration of protein prenylation induces cardiomyocyte hypertrophy through Rheb–mTORC1 signaling and leads to chronic heart failure. Journal of pathology, 2014, 235(5): 672-685.
  • Shanshan Lai, Jun Yuan, Dandan Zhao, Ning Shen, Weibo Chen, Yao Ding, Decai Yu, Jing Lie, Feiyan Pan, Minsheng Zhu, Chaojun Li, Bin Xue*, Regulation of mice liver regeneration by early growth response-1 through the GGPPS/RAS/MAPK pathway. The International Journal of Biochemistry & Cell Biology, 2015, 64:147–154.
  • Gu Dai, Yan Qian, Jie Chen, Fan-Li Meng, Fei-Yan Pan, Wei-Gan Shen, Sheng-Zhou Zhang, Bin Xue, and Chao-Jun Li, Calmodulin activation of polo-like kinase 1 is required during mitotic entry. Biochemistry and Cell Biology, 2013, 91(5): 287-294.
  • Yu X, Shen N, Zhang ML, Pan FY, Wang C, Jia WP, Liu C, Gao Q, Gao X, Xue B, Li CJ: Egr-1 decreases adipocyte insulin sensitivity by tilting PI3K/Akt and MAPK signal balance in mice. The EMBO Journal, 2011, 30(18): 3754-3765.
  • Shen N, Yu X, Pan F-Y, Gao X, Xue B, Li C-J: An early response transcription factor, Egr-1, enhances insulin resistance in type 2 diabetes with chronic hyperinsulinism. Journal of Biological Chemistry, 2011, 286:14508-14515.
  • Shen N, Gong T, Wang J-D, Meng F-L, Qiao L, Yang R-L, Xue B, Pan F-Y, Zhou X-J, Chen H-Q, Ning W, Li C-J: Cigarette Smoke-Induced Pulmonary Inflammatory Responses Are Mediated by EGR-1/GGPPS/MAPK Signaling. The American Journal of Pathology, 2011, 178(1): 110-118. 
  • Pan F-Y, Zhang S-Z, Xu N, Meng F-L, Zhang H-X, Xue B, Han X, Li C-J: β-catenin signaling involves HGF-enhanced HepG2 scattering through activating MMP-7 transcription. Histochemistry and Cell Biology, 2010, 134(3): 285-295.
  • Peng W*, Pan F*, Liu X, Shen N, Xu Na, Meng F, Wang Y, Li C: Hypoxia stabilizes Microtubule Networks and Decreases Tumor Cell Chemosensitity to Anticancer Drugs Through Egr-1. Anatomical record, 2010, 293:414-420.

Books

Li Chaojun, Pan Feiyan, Dai Gu, Liang Juan. 2010. Translated book: The Cell Cycle: Principles of Control. 

Academic Title

Chinese Society for Cell Biology, member

Contact 

E-mail: panfeiyan@njnu.edu.cn