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Faculty

Guangdong Shang Associate Professor

Research Interests: 
  • Synthetic Biology
  • Recombineering
  • Biocatalysis
Bio: 

Educational Background

PhD, Microbial Pharmacy, Chinese Academy of Medical Sciences (1999)

MA, Biochemistry, China Pharmaceutical university (1996)

BA, Pharmacology, China Pharmaceutical university (1990)

Research Project

  • Recombineering-mediated directed evolution of N-acetylneuraminic acid aldolase (NSFC 81273412). 2013.1.1-2016.12.31

Journal Articles

  • Luo X, Yang Y, Ling W, Zhuang H, Li Q, Shang G. Pseudomonas putida KT2440 markerless gene deletion using a combination of λ Red recombineering and Cre/loxP site-specific recombination. FEMS Microbiol Lett. 2016 Feb; 363(4). pii: fnw014.  
  • Luo X, Li L, Chai M, Zhang Q, Shang G. Escherichia coli BL21(DE3) chromosome-based controlled intracellular processing system for fusion protein separation. J Microbiol Methods. 2015 July; 114:35-37.  
  • Long FQ, Zhang JP, Shang GD, Shang SX, Gong KL, Wang QQ. Seroreactivity and immunogenicity of Tp0965, a hypothetical membrane protein  of Treponema pallidum. Chin  Med J (Engl). 2012 Jun; 125(11):1920-4.
  • Wu Y, Kang Q, Shang G, Spiteller P, Carroll B, Yu TW, Su W, Bai L, Floss HG. N-methylation of the amide bond by methyltransferase asm10 in ansamitocin biosynthesis. Chembiochem. 2011 Jul 25; 12(11):1759-66. 
  • Dai W, He W, Shang G, Jiang J, Wang Y, Kong W. Gene silencing of myofibrillogenesis regulator-1 by adenovirus-delivered small interfering RNA suppresses cardiac hypertrophy induced by angiotensin II in mice. Am J Physiol Heart Circ Physiol. 2010 Nov; 299(5):1468-75.  
  • Wei M, Wang S, Shang G. Biosynthetic Pathways and Engineering for Bioactive Natural Products. Curr Org Chem. 2010 Aug; 14(14):1433-1446.
  • Song J, Dong H, Ma C, Zhao B, Shang G. Construction and functional characterization of an integrative form lambda Red recombineering Escherichia coli strain. FEMS Microbiol Lett. 2010 Aug 1; 309(2):178-83.  
  • Bandi S, Kim Y, Chang Y, Shang G, Yu TW, Floss HG. Construction of asm2 deletion mutant of Actinosynnema pretiosum and medium optimization for ansamitocin P-3 production using statistical approach. J Microbiol Biotechnol. 2006 Sep; 16(9):1338-1346.
  • Spiteller P, Bai L, Shang G, Carroll BJ, Yu TW, Floss HG. The post-polyketide synthase modification steps in the biosynthesis of the antitumor agent ansamitocin by Actinosynnema  pretiosum. J Am Chem Soc. 2003 Nov 26; 125(47):14236-7.
  • Shang G, Dai J, Wang Y. Construction and physiological studies on a stable bioengineered strain of shengjimycin. J Antibiot (Tokyo). 2001 Jan; 54(1):66-73.
  • Shang G, Wang Y. Cloning of a regulatory gene from Streptomyces cattleya and study on its cis-acting element. Sci China C Life Sci. 2000 Aug; 43(4):418-24.

Patents

Shang Guangdong, Xie Feng. A method for cloning of multiple fragments into a vector. Patent No. ZL200710019865.2.

Shang Guangdong, Song Jie, Huang Huiying. An Escherichia coli strain for recombineering. Patent No. ZL200910184219.0.

Shang Guangdong, Yang Yunwen, Song Jie, Gao Jiucai. A highly efficient gene deletion method for Pseudomonas putida KT2440. Patent No. ZL201010575202.0.

Shang Guangdong, Li Ling, Yan Zheng Ya, Shi Modan. An Escherichia coli strain for the production of N-acetylneuraminic acid. ZL201310222109.5

Contact 

Tel: +86-25-89898332

E-mail: shanggd@hotmail.com