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Haijia Yu Professor

Research Interests: 
  • Regulation of insulin stimulated GLUT4 exocytosis in adipocytes
  • Mechanisms of Sec1/Munc18 proteins in membrane trafficking
  • Intracellular membrane contact sites and cell-cell communications

Educational Background

Postdoctoral research associate, University of Colorado at Boulder (2017)

Ph.D., Changchun Institute of Applied Chemistry, Chinese Academy of Sciences (2009)

B.S., Northeast Normal University (2003)

Research Projects

National Natural Science Foundation of China (31871425, 91854117)

Journal Articles
•    Chong Shen#, Yinghui Liu#, Haijia Yu*, Daniel R. Gulbranson, Igor Kogut, Ganna Bilousova, Chen Zhang, Michael H. B. Stowell, Jingshi Shen*, The N-peptide-binding mode is critical to Munc18-1 function in synaptic exocytosis,J. Biol. Chem., 2018, 293,18309-18317. ( #equal first author, *Corresponding author)
•    Haijia Yu*, Lauren Crisman, Michael H. B. Stowell, and Jingshi Shen*, Functional reconstitution of intracellular vesicle fusion using purified SNAREs and Sec1/Munc18 (SM) proteins. Methods Mol. Biol. 2018, 1860, 237-249. 
•    Haijia Yu, Chong Shen, Yinghui Liu, Bridget L. Menasche, Yan Ouyang, Michael H. B. Stowell*, and Jingshi Shen*,SNARE zippering requires activation by SNARE-like peptides in Sec1/Munc18 proteins,Proc. Natl. Acad. Sci. U S A, 2018, 115, E8421-8429. 
•    Daniel R. Gulbranson, Eric M. Davis, Brittany A. Demmitt, Yan Ouyang, Yihong Ye, Haijia Yu*, Jingshi Shen*, RABIF/MSS4 is a Rab-stabilizing holdase chaperone required for GLUT4 exocytosis. Proc. Natl. Acad. Sci. U S A, 2017, 114, E8224-E8233. 
•    Haijia Yu, Yinghui Liu, Daniel R. Gulbranson, Alex Paine, Shailendra S. Rathore, and Jingshi Shen*,Extended synaptotagmins are Ca2+-dependent lipid transfer proteins at membrane contact sites,Proc. Natl. Acad. Sci. U S A, 2016, 113, 4362-4367. 
•    Chong Shen#, Shailendra S. Rathore#, Haijia Yu#, Daniel R. Gulbranson, Rui Hua, Chen Zhang, Nathan E. Schoppa, and Jingshi Shen*,The trans-SNARE-regulating function of Munc18-1 is essential to synaptic exocytosis, Nat. Commun., 2015, 6, 8852. 
•    Haijia Yu#, Shailendra S. Rathore#, Chong Shen, Yinghui Liu, Yan Ouyang, Michael H. Stowell, Jingshi Shen*, Reconstituting Intracellular Vesicle Fusion Reactions: The Essential Role of Macromolecular Crowding, J. Am. Chem. Soc., 2015, 137, 12873-12883. 
•    Haijia Yu, Shailendra S. Rathore, Daniel R. Gulbranson, Jingshi Shen*, The N- and C-terminal domains of tomosyn play distinct roles in SNARE binding and fusion regulation, J. Biol. Chem., 2014, 289, 25571-25580. 
•    Haijia Yu, Shailendra S. Rathore, Jamie A. Lopez, Eric M. Davis, David E. James, Jennifer L. Martin, Jingshi Shen*, Comparative studies of Munc18c and Munc18-1 reveal conserved and divergent mechanisms of Sec1/Munc18 proteins, Proc. Natl. Acad. Sci. U S A, 2013, 110, E3271-3280. 
•    Haijia Yu, Shailendra S. Rathore, Eric M Davis, Yan Ouyang, Jingshi Shen*, Doc2b promotes GLUT4 exocytosis by activating the SNARE-mediated fusion reaction in a calcium- and membrane bending-dependent manner, Mol. Biol. Cell., 2013, 24, 1176-1184. 
•    Haijia Yu, Shailendra S. Rathore, Jingshi Shen*, Synip Arrests Soluble N- Ethylmale imide-sensitive Factor Attachment Protein Receptor (SNARE)-dependent Membrane Fusion as a Selective Target Membrane SNARE-binding Inhibitor,J. Biol. Chem., 2013, 288,18885-18893. 
•    Haijia Yu#, Meng Li#, Gongping Liu#, Jie Geng, Jianzhi Wang, Jinsong Ren, Chuanqi Zhao, Xiaogang Qu*, Metallosupramolecular complex targeting an α/β discordant stretch of amyloid β peptide, Chem. Sci., 2012, 3, 3145-3153. 
•    Shailendra S. Rathore, Eric G. Bend, Haijia Yu, Marc Hammarlund, Erik M. Jorgensen, Jingshi Shen*, Syntaxin N-terminal peptide motif is an initiation factor for the assembly of the SNARE-Sec1/Munc18 membrane fusion complex, Proc. Natl. Acad. Sci. U S A, 2010, 107, 22399-22406. 
•    Haijia Yu, Chuanqi Zhao, Yong Chen, Manliang Fu, Jinsong Ren, Xiaogang Qu*, DNA loop sequence as the determinant for chiral supramolecular compound G-quadruplex selectivity, J. Med. Chem., 2010, 53, 492–498. 
•    Haijia Yu, Xiaohui Wang, Manliang Fu, Jinsong Ren, Xiaogang Qu*, Chiral metallo-supramolecular complexes selectively recognize human telomeric G-quadruplex DNA, Nucleic Acids Res., 2008, 36, 5695-5703. 
•    Haijia Yu, Jinsong Ren, Jonathan B. Chaires, Xiaogang Qu*, Hydration of Drug-DNA Complexes: Greater Water Uptake for Adriamycin Compared to Daunomycin, J. Med. Chem., 2008, 51, 5909–5911. 
•    Haijia Yu, Jinsong Ren, Xiaogang Qu*, Different Hydration Changes Accompanying Copper and Zinc Binding to Amyloid β-Peptide: Water Contribution to Metal Binding, ChemBioChem, 2008, 9, 879-882. 
•    Jie Geng, Haijia Yu, Jinsong Ren, Xiaogang Qu*, Rapid label-free detection of metal-induced Alzheimer's amyloid beta-peptide aggregation by electrochemical method, Electrochem. commun., 2008, 10, 1797-1800. 
•    Haijia Yu, Jinsong Ren, Xiaogang Qu*, Time-Dependent DNA Condensation Induced by Amyloid β-Peptide, Biophys. J., 2007, 92, 185-191. 
•    Haiyuan Zhang, Haijia Yu, Haixia Xu, Jinsong Ren, Xiaogang Qu*, Structural diversity of lanthanide-amino acid complexes under near physiological pH conditions and their recognition of single-stranded DNA, Polyhedron, 2007, 26, 5250-5256. 
•    Huixin Bao, Xiaohui Wang, Haijia Yu, Manliang Fu, Xiaogang Qu*,Yongchen Zheng, Jinsong Ren, Physical and spectral characterization of the human cyclin A gene and its interactions with anthracycline anticancer drugs, Chem. Phys. Lett., 2007, 436, 252-257. 
•    Haiyuan Zhang, Haijia Yu, Jinsong Ren, Xiaogang Qu*, Reversible B/Z-DNA transition under the low salt condition and non-B-form polydApolydT selectivity by a cubane-like europium-L-aspartic acid complex, Biophys. J., 2006, 90, 3203-3207. 
•    Haiyuan Zhang, Haijia Yu, Jinsong Ren, Xiaogang Qu*, PolydA and polyrA self-structured by a europium and amino acid complex, FEBS Lett., 2006, 580, 3726-3730. 


Use of metal supermolecular compound in preparation of medicament for treating Alzheimer's disease. China patent ZL201010132825.0

Honors and Awards

Specially-Appointed Professor in Jiangsu Province;
The First Class Prize of Science and Technology Progress of Jilin Province