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Huaqun Chen Professor

Research Interests: 
  • Regulation of endothelial cell permeability
  • Biology of skeletal muscle

Educational Background 

PhD, Cell Biology, Nanjing Normal University (2006)

MA, Biochemistry, Nanjing Medical University (1992)

BA, Biology, Shan’xi Nornal University (1989)

Research Projects

  • National natural science foundation of China: 30971540, 31371356   

Journal Articles 

  • Gao YQ, Chen X, Wang P, Lu L, Zhao W, Chen C, Chen CP, Tao T, Sun J, Zheng YY, Du Jie, Li CJ, Gan ZJ, Gao X, Chen HQ and Zhu MS. Regulation of DLK1 by the maternally expressed miR-379-544 cluster may underlie callipyge polar overdominance inheritance.PNAS 112(44):13627-32, 2015
  • Chen C, Tao T, Wen C, He WQ, Qiao YN, Gao YQ, Chen X, Wang P, Chen CP, Zhao W, Chen HQ, Ye AP, Peng YJ, Zhu MS. Myosin light chain kinase (MLCK) regulates cell migration in a myosin regulatory light chain phosphorylation-independent mechanism. J Biol Chem. 289(41):28478-88, 2014
  • Yu Y, Lv N, Lu Z, Zheng YY, Zhang WC, Chen C, Peng YJ, He WQ, Meng FQ, Zhu MS, Chen HQ.Deletion of myosin light chain kinase in endothelial cells has a minor effect on the lipopolysaccharide- induced increase in microvascular endothelium permeability in mice. FEBS J. 279(8):1485-94, 2012 (corresponding author)
  • Wang L, Chen X, Zheng Y, Li F, Lu Z, Chen C, Liu J, Wang Y, Peng Y, He W, Zhu M, Chen H. MiR-23a inhibits myogenic differentiation through down regulation of fast myosin heavy chain isoforms. Exp Cell Res. 318(18): 2324-34, 2012 (corresponding author)
  • Cao D, Wang C, Tang R, Chen H, Zhang Z, Tatsuguchi M, Wang DZ.Acetylation of myocardin is required for the activation of cardiac and smooth muscle genes. J Biol Chem. 287(46):38495-504, 2012
  • Shen N, Shao Y, Lai SS, Qiao L, Yang RL, Xue B, Pan FY, Chen HQ, Li CJ.GGPPS, a new EGR-1 target gene, reactivates ERK 1/2 signaling through increasing Ras prenylation. Am J Pathol. 179(6): 2740-50, 2011 (co-corresponding author)
  • Chen H, Wang L, Gong T, Yu Y, Zhu C, Li F, Wang L, Li C. EGR-1 regulates HO-1 Expression induced by cigarette smoke,Biochem Biophys Res Commun. 96(2):388-93, 2010 (co-corresponding author)
  • Zhang WC, Peng YJ, He WQ, Chen C, Zhi G, Zhen HQ, Chen HQ, Zhu MS. Identification and functional characterization of an aggregation domain in long myosin light chain kinase. FEBS J, 275(10): 2489-500, 2008
  • He WQ, Peng YJ, Zhang WC, Lv N, Tang J, Chen C, Zhang CH, Gao S, Chen HQ, Zhi G, Feil R, Kamm KE, Stull JT, Gao X, Zhu MS. Myosin light chain kinase is central to smooth muscle contraction and required for gastrointestinal motility in mice. Gastroenterology, 135(2): 610-20, 2008
  • Pan Y, Shen Y, Chen C, Zhu CH, Wang XC, Wang G, Chen HQ and Zhu MS. Curcumin alleviates dystrophic muscle pathology in mdx mice. Molecules and Cells. 25 (4):531-537, 2008 (co-corresponding author)