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Faculty

Ling Lu Professor

Research Interests: 
  • Validation of functional genes, genomics, and gene regulation in the model fungus Aspergillus nidulans.
  • Screening and identification novel mutated genes conferring azole resistance for clinic isolates of Aspergillus fumigatus.
  • Set-up molecular and biochemistry techniques to understand the azole-resistance mechanism.
  • Developing new antibiotics and alternative approaches to prevent resistant fungal pathogen in the immune-compromised host.
  • Understanding and exploitation for bioactive materials from medicinal mushroom Pleurotus eryngii.
Bio: 

Educational Background

1981-1988  B. A & M.S   Nanjing Agricultural University,   Major in Biochemistry and Plant Physiology    

1995-1998  Ph.D  Nanjing Agricultural University, Major in Microbiology

Research Experiences

1991-1995 Assistant Professor in Nanjing Normal University.

1996-2001 Associate Professor in Nanjing Normal University. 

2002-2004 Visiting Scholar in College of Biological Sciences, University of California, Davis, USA. 

2004-2005 Postdoctoral Researcher in Dept. of Internal Medicine, University of California, Davis, USA.

2005-2007 Professor in School of Life Sciences, Nanjing Normal University.

2007-2009 Research Associate in Dept. of Internal Medicine, University of California, Davis, USA.

2009-current Senior Professor in School of Life Sciences, Nanjing Normal University, China.

Research Projects

  • Molecular mechanism of calcium signaling pathway involved in multi-azole drug resistances in the Aspergilli (NSFC Grants).
  • Regulation of suppressers of septum initiation network (SIN) on cytokinesis in Aspergillus nidulans (NSFC Grants).
  • Hepatoprotective and hypolipidemic effects of  water-soluble polysaccharidic extract of Pleurotus eryngii.
  • Preparation of nano silver antimicrobial safety medical materials.

Journal Articles (Recent Major Publications)

  • Zhang Y, Zhen QQ, Sun CC, Song J, Gao LN, Zhang SZ, Muñoz A., Read N. Lu, L (2016) Palmitoylation of the cysteine residue in the DHHC motif of a palmitoyl transferase mediates Ca2+ homeostasis in Aspergillus. PLOS Genetics 8; 12 (4): e1005977. doi: 10.1371/journal.pgen.1005977. 
  • Song J, Zhai P, Zhang Y, Zhang C, Sang H, Han G, Keller NP, Lu, L (2016) The Aspergillus fumigatus damage resistance protein family coordinately regulates ergosterol biosynthesis and azole susceptibility. mBIO. 23; 7(1). pii: e01919-15. doi: 10.1128/mBio.01919-15  
  • Long N, Xu X, Qian H, Zhang S and Lu, L (2016) A putative mitochondrial iron transporter MrsA in Aspergillus fumigatus plays important roles in azole-, oxidative stress responses and virulence. Frontiers in Microbiology 7:716. doi: 10.3389/fmicb.2016.00716 
  • Song J, Liu X, Zhai P, Huang J, Lu, L. (2016) A putative mitochondrial calcium uniporter in A. fumigatus contributes to mitochondrial Ca(2+) homeostasis and stress responses. Fungal Genetics & Biology 94:15-22. doi: 10.1016/j.fgb.
  • Wang S, Liu X, Qian H, Zhang S, Lu L (2016) Calcineurin and calcium channel CchA coordinate the salt stress response by regulating the cytoplasmic Ca2+ homeostasis in Aspergillus nidulans. Applied and Environmental Microbiology 16; 82(11): 3420-30. doi: 10.1128/AEM.00330-1. 
  • Cai Z, Chai Y, Zhang C, Feng R, Sang H, Lu, L (2016) Molecular Characterization of Gβ-Like Protein CpcB Involved in Antifungal Drug Susceptibility and Virulence in A. fumigatus. Frontiers in Microbiology 7:106. doi: 10.3389/fmicb.2016.00106. 
  • Zhang C, Meng X, Wei X, Lu, L (2016) Highly efficient CRISPR mutagenesis by microhomology-mediated end joining in Aspergillus fumigatus. Fungal Genetics & Biology 86:47-57. doi: 10.1016
  • Chen, P.; Yong, Y.; Gu, Y.; Wang, Z.; Zhang, S.; Lu, L (2015) Comparison of antioxidant and antiproliferation activities of polysaccharides from eight species of medicinal mushrooms. International Journal of Medicinal Mushrooms, 17, 287-95.
  • Liu, F. F.; Pu, L.; Zheng, Q. Q.; Zhang, Y. W.; Gao, R. S.; Xu, X. S.; Zhang, S. Z.; Lu, L ( 2015) Calcium signaling mediates antifungal activity of triazole drugs in the Aspergilli. Fungal genetics and biology : Fungal Genetics & Biology, 81, 182-90.
  • Zheng, H., Zhang, S., Zhang, S., and Lu, L (2015) Riboflavin Level Manipulates the Successive Developmental Sequences in Aspergillus nidulans. Current Microbiology 70, 637-642
  • Cai, Z. D.; Chai, Y. F.; Zhang, C. Y.; Qiao, W. R.; Sang, H.; Lu, L., (2015) The Gbeta-like protein CpcB is required for hyphal growth, conidiophore morphology and pathogenicity in Aspergillus fumigatus. Fungal genetics and biology : Fungal Genetics & Biology 2015, 81, 120-31.
  • Wei, X., Zhang, Y., and Lu, L. (2015) The molecular mechanism of azole resistance in Aspergillus fumigatus: from bedside to bench and back. Journal of Microbiology 53, 91-99
  • Lu, L., Sirish, P., Zhang, Z., Woltz, R. L., Li, N., Timofeyev, V., Knowlton, A. A., Zhang, X. D., Yamoah, E. N., and Chiamvimonvat, N. (2015) Regulation of gene transcription by voltage-gated L-type calcium channel, Cav1.3. The Journal of Biological Chemistry 290, 4663-4676
  • Zhong, G. W., Jiang, P., Qiao, W. R., Zhang, Y. W., Wei, W. F., and Lu, L. (2014) Protein Phosphatase 2A (PP2A) Regulatory Subunits ParA and PabA Orchestrate Septation and Conidiation and Are Essential for PP2A Activity in Aspergillus nidulans. Eukaryotic Cell 13, 1494-1506
  • Zhang, S. Z., Zheng, H. L., Long, N. B., Carbo, N., Chen, P. Y., Aguilar, P. S., and Lu, L. (2014) FigA, a Putative Homolog of Low-Affinity Calcium System Member Fig1 in Saccharomyces cerevisiae, Is Involved in Growth and Asexual and Sexual Development in Aspergillus nidulans. Eukaryotic Cell 13, 295-303
  • Jiang, H. C., Liu, F. F., Zhang, S. Z., and Lu, L. (2014) Putative PmrA and PmcA are important for normal growth, morphogenesis and cell wall integrity, but not for viability in Aspergillus nidulans. Microbiol-Sgm 160, 2387-2395
  • Jiang, H., Shen, Y., Liu, W., and Lu, L. (2014) Deletion of the putative stretch-activated ion channel Mid1 is hypervirulent in Aspergillus fumigatus. Fungal Genetics & Biology 62, 62-70
  • Chen, J., Yong, Y., Xia, X., Wang, Z., Liang, Y., Zhang, S., and Lu, L. (2014) The excreted polysaccharide of Pleurotus eryngii inhibits the foam-cell formation via down-regulation of CD36. Carbohydrate Polymers 112, 16-23
  • Chen, J., Yong, Y., Xing, M., Gu, Y., Zhang, Z., Zhang, S., and Lu, L. (2013) Characterization of polysaccharides with marked inhibitory effect on lipid accumulation in Pleurotus eryngii. Carbohydrate Polymers 97, 604-613
  • Zhong, G. W., Wei, W. F., Guan, Q., Ma, Z. F., Wei, H., Xu, X. S., Zhang, S. Z., and Lu, L. (2012) Phosphoribosyl pyrophosphate synthetase, as a suppressor of the sepH mutation in Aspergillus nidulans, is required for the proper timing of septation. Molecular Microbiology 86, 894-907 
  • Chen, P. Y., Gao, R. S., Chen, S. C., Pu, L., Li, P., Huang, Y., and Lu, L (2012) A Pericentrin-Related Protein Homolog in Aspergillus nidulans Plays Important Roles in Nucleus Positioning and Cell Polarity by Affecting Microtubule Organization. Eukaryotic Cell 11, 1520-1530
  • Wang S, Cao J, Liu X, Hu H, Shi J, Zhang S, Keller NP, Lu, L (2012) Putative Calcium Channels CchA and MidA Play the Important Roles in Conidiation, Hyphal Polarity and Cell Wall Components in Aspergillus nidulans. PLoS One; 7(10):e46564 
  • Chen, J., Mao, D., Yong, Y., Li, J., Wei, H., Lu L (2012) Hepatoprotective and hypolipidemic effects  of  water-soluble  polysaccharidic  extract  of  Pleurotus  eryngii. Food  Chemistry 130: 687-694
  • Gao, L. N., Song, Y. J., Cao, J. L., Wang, S., Wei, H., Jiang, H. C., and Lu, L. (2011) Osmotic stabilizer-coupled suppression of NDR defects is dependent on the calcium-calcineurin signaling cascade in Aspergillus nidulans. Cell Signalling 23, 1750-1757 
  • Chen, S. C., Song, Y. J., Cao, J. L., Wang, G., Wei, H., Xu, X. S., and Lu, L (2010) Localization and function of calmodulin in live-cells of Aspergillus nidulans. Fungal Genetics & Biology 47, 268-278  
  • Wang, J. J., Hu, H. Q., Wang, S., Shi, J., Chen, S. C., Wei, H., Xu, X. S., and Lu, L (2009) The important role of actinin-like protein (AcnA) in cytokinesis and apical dominance of hyphal cells in Aspergillus nidulans. Microbiology-Sgm 155, 2714-2725
  • Lu, L., Timofeyev, V., Li, N., Rafizadeh, S., Singapuri, A., Harris, T. R., and Chiamvimonvat, N. (2009) Alpha-actinin2 cytoskeletal protein is required for the functional membrane localization of a Ca2+-activated K+ channel (SK2 channel). Proceedings of the National Academy of Sciences of the United States of America 106, 18402-18407

Honors and Awards 
        
Award for Excellent in Science and Technology from Jiangsu Province.

Scholarship Award in Nanjing Agricultural University.

Award for Outstanding Teacher in Nanjing Normal University.

Award for Excellent Research Leader in Nanjing Normal University.

Currently professional societies involved

Associate Editor for“Fungal Genetics & Biology”; Editor for “Journal of Microbiology”.

Peer Reviewer for Journals: Molecular Microbiology; Applied and Environmental Microbiology;Environmental Microbiology ; Fungal Genetics & Biology.

Committee Member for Aspergillus Genomes Research Policy Committee; Mycology Society in China and Microbiology Society in China. 

Members for American Society for Microbiology; Genetics Society of America; American Society for Cell Biology.

Contact

Phone/Fax : +86-25-85891791(o)

Email: linglu@njnu.edu.cn; linglu6465@hotmail.com