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Faculty

Lingfeng He Lecturer

Research Interests: 
DNA damage and cancer biology
Bio: 

Educational Background

Post-doctoral research, Beth Israel Medical Center and Harvard medical school, USA. (2013)

PhD, Biochemistry and Molecular biology, Shanghai Institutes for Biological Sciences, CAS. (2008)

MA, Biochemistry and Molecular biology, Shanghai Institutes for Biological Sciences, CAS. (2005)

BA, Marine biology. Ocean university of China. (1994)

Research Projects

  • The Jiangsu Provincial Natural Science Foundation (BK20141448 ).
  • The Project Sponsored by the Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry (2015104SBJ0090). 

Journal Articles

  • Lingfeng He, Huan Yang,  Shiying Zhou, Hong Zhu, Huiwen Mao, Zhuang Ma, Ting Wu,Alagamuthu Karthick Kumar, Chandrasekhar Kathera, Avilala Janardhan, Feiyan Pan, Zhigang Hu, Yanhua Yang, Libo Luo, Zhigang Guo. Synergistic antitumor effect of combined paclitaxel with FEN1 inhibitor in cervical cancer cells. DNA Repair 63 (2018) 1–9.
  • Lingfeng He, Hong Zhu, Huan Yang, Huan Wu, Hongfang Sun, Feng Jiang, Chandra Sekhar Kathera, Yilan Zhang, Haoyan Chen, Feiyan Pan, Zhigang Hu, Zhigang Guo. FEN1 Promotes Tumor Progress and Confers Cisplatin Resistance in Non-Small Cell Lung Cancer.  Molecular Oncology. 2017 Jun;11(6):640-654. doi: 10.1002/1878-0261.12058. Epub 2017 May 12.
  • Chandrasekhar kathera, Hongfang Sun, Wajid Ali, Xiaolong Zhou, Lingfeng He, Zhigang Guo. Interacting partners of FEN1 and its role in the development of anticancer therapeutics. Oncotarget. 2017 Feb 7. doi: 10.18632/oncotarget.15176. [Epub ahead of print]
  • Xiaolong Zhou, Ziheng Zhuang, Wentao Wang, Lingfeng HeCo-First author, Huan Wu, Yan Cao, Feiyan Pan, Jing Zhao, Zhigang Hu, Chandra Sekhar, Zhigang Guo. OGG1 is essential in oxidative stress induced DNA demethylation. Cell Signal. 2016 Sep;28(9):1163-71. doi: 10.1016/j.cellsig.2016.05.021. Epub 2016 May 29.
  • Yan Cao, Huan Yang, Xiaolong Zhou, Huiwen Mao, Tingting Gao, Zhigang Hu, Lingfeng He, Feiyan Pan, Zhigang Guo. Selection and characterization of human PCSK9 antibody from phage displayed antibody library,Biochemical and Biophysical Research Communications 463 (2015) 712-718.
  • Ma F, Ye H, He HH, Gerrin SJ, Chen S, Tanenbaum BA, Cai C, Sowalsky AG, He L, Wang H, Balk SP, Yuan X. SOX9 drives WNT pathway activation in prostate cancer. J Clin Invest.  2016 May 2;126(5):1745-58. doi: 10.1172/JCI78815. Epub 2016 Apr 4.
  • Hongyun Wang*, Lingfeng He*, Fen Ma, Meredith Regan, Steven Balk, Andrea Richardson and Xin Yuan. SOX9 Regulates Low-Density Lipoprotein Receptor–related Protein 6 and T-cell Factor 4 Expression and Wnt/β-Catenin Activation in Breast Cancer. The Journal of Biological Chemistry,VOL. 288, NO. 9, pp. 6478–6487, March 1, 2013
  • Changmeng Cai, Hongyun Wang, Housheng Hansen He, Sen Chen, Lingfeng He, Lorelei Mucci, Qianben Wang, Christopher Fiore, Adam Sowalsky, Massimo Loda, Xiaole Shirley Liu, Myles Brown, Steven P. Balk and Xin Yuan. ERG induces androgen receptor-mediated regulation of SOX9 in prostate cancer. The Journal of Clinical Investigation, Volume 123 Number 3 March 2013
  • Ling Feng He, Yi Gang Wang, Tian Xiao, Kang Jiang Zhang, Gong Chu Li, Jin Fa Gu, Liang Chu, Wen Hao Tang, Wen-Song Tan, Xin Yuan Liu. Suppression of cancer growth in mice by adeno associated virus vector mediated IFN-b expression driven by hTERT promoter. Cancer Letters 286 (2009) 196–205.   
  • Ling Feng He, Jin Fa Gu, Wen Hao Tang, Jun Kai Fan, Na Wei, Wei Guo Zou, Yan Hong Zhang, Li Li Zhao, Xin Yuan Liu.  Significant antitumor activity of oncolytic adenovirus expressing human interferon-βfor hepatocellular carcinoma.  The Journal of Gene Medicine, 2008; 10: 983–992.   
  • Yanhong Zhang, Jinfa Gu, Lili Zhao, Lingfeng He, Wenbin Qian, Jinhui Wang, Yigang Wang, Qijun Qian, Cheng Qian, Jian Wu and Xin Yuan Liu. Complete Elimination of Colorectal Tumor Xenograft by Combined Manganese Superoxide Dismutase with Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand Gene Virotherapy.  Cancer Research. 2006 66: 4291-4298. 
  • Hongling Huang, Tian Xiao, Lingfeng He, Hongbin Ji, and Xin-Yuan Liu.Interferon-b-armed oncolytic adenovirus induces both apoptosis and necroptosis in cancer cells. Acta Biochimica et Biophysica Sinica. 2012 Sep;44(9):737-45
  • Na Wei, Jun Kai Fan, Jin Fa Gu, Ling Feng He, Wen Hao Tang, Xin Cao, Xin Yuan Liu. A double regulated oncolytic adenovirus with improved safety for adenocarcinoma therapy. Biochemical and Biophysical Research Communications 388 (2009) 234–239
  • Jn Kai Fan, Tian Xiao, Jin Fa Gua, Na Wei, Ling Feng He, Miao Ding, Xin Yuan Liu. Increased suppression of oncolytic adenovirus carrying mutant k5 on colorectal tumor. Biochemical and Biophysical Research Communications 374 (2008) 198-203.
  • Lili Zhao, Jinfa Gu, Aiwen Dong, Yanhong Zhang, Liu Zhong, Lingfeng He, Jinghe Zhang, Zilai Zhang, Jinhui Wang, Qijun Qian, Cheng Qian, and Xin Yuan Liu. Potent Antitumor Activity of Oncolytic Adenovirus Expressing mda-7/IL24 for Colorectal Cancer.  Human Gene Therapy. 16:845-858 (July 2005)  

Contact

E-mail:lfhe22@139.com