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Shan Lu Professor

Research Interests: 
To investigate the mechanism related to the occurrence and development of prostate cancer, identify molecular targets, and develop effective therapeutic approaches for prostate cancer. 

Educational Background

Postdoc research: Cincinnati University College of Medicine (2004-2009)

Ph.D.: Bioresource Science, Tottori University, Japan (2004)

M.S.: Food Engineering and Biotechnology, Tianjin University of Science & Technology (1994)

B.S.: Food Engineering and Biotechnology, University of Pennsylvania, (1991)

Research Projects

  • The role of Smad3 in the progression of prostate cancer supported by NSFC

Journal Articles

  • Lu S, Zhu Q, Zhang Y, Song W, Wilson MJ, Liu P.Dual-Functions of miR-373 and miR-520c by Differently Regulating the Activities of MMP2 and MMP9.J Cell Physiol 230 (8) pp1862-1870, 2015
  • Lu S, Tan Z, Wortman M, Lu S, Dong Z. Preferential induction of G1 arrest in androgen-responsive human prostate cancer cells by androgen receptor signaling antagonists DL3 and antiandrogen bicalutamide Cancer Letters 298 (2) pp250-257, 2010 
  • Lu S, Tan Z, Wortman M, Lu S, Dong Z. Regulation of heat shock protein 70-1 expression by androgen receptor and its signaling in human prostate cancer cells. Int J Oncol 36 (2) pp 459-67, 2010 
  • Lu S, Wang A, Lu S, Dong Z. A novel synthetic compound that interrupts androgen receptor signaling in prostate cancer cells. Mol Cancer Therapeutics 6 (7), pp 2057-2064,2007
  • Lu S, Lee J, Reveio M, Wang X, Lu S, Dong Z. Smad3 is overexpressed in advanced human prostate cancer and necessary for progressive growth of prostate cancer cells in nude mice. Clin Cancer Res 13 (19) pp5692-5702,2007 
  • Lu S, Dong Z. Characterization of TGF-beta-regulated interleukin-8 expression in human prostate cancer cells. The Prostate 66 (9) pp 996-1004,2006 (IF3.7)
  • Lu S, Nishimura K, Hossain M A, Jisaka M, Nagaya T, and Yokota K. Regulation and role of arachidonate cascade during the changes in the life cycle of adipocytes. Appl. Biochem. Biotechnol 118 (1-3) pp 133-53, 2004 
  • Lu S, Ohya M, Nishimura K, Jisaka M, Nagaya T, Yokota K. Specific gene expression of isoforms in cyclooxygenase pathway to generate PGJ2 derivatives during the differentiation of 3T3-L1 adipocytes. Adv Exp Med Biol 525 pp 153-156, 2003 
  • Fan L, Liu L, Zhu C, Zhu Q, Lu S, Liu P. MT1-MMP Inhibits the Activity of Bst-2 via Their Cytoplasmic Domains Dependent Interaction.Int J Mol Sci 17(6).ppE818, 2016 
  • Liu Y, Mo J, Hu Q, Boivin G, Levin L, Lu S, Yang D, Dong Z, Lu S. Targeted overexpression of Vav3 oncogene in prostatic epithelium induces nonbacterial prostatitis and prostate cancer. Cancer Res 68 (15) pp 6396-6406,2008
  • Wang D, Lu S, Dong Z. Regulation of TGF-beta 1 gene transcription in human prostate cancer cells by nitric oxide. The Prostate 67 (16) pp1825-1833,2007 
  • Dong Z, Liu Y, Lu S, Wang A, Lee K, Wang LH, Revelo M,Lu S. Vav3 oncogene is overexpressed and regulates cell growth and androgen receptor activity in human prostate cancer. Mol Endocrinol. 20 (10) pp 2315-25,2006 
  • Zhang F, Lee J, Lu S, Pettaway CA, Dong Z. Blockade of transforming growth factor-beta signaling suppresses progression of androgen-independent human prostate cancer in nude mice. Clin Cancer Res 11 (12) pp 4512-20,2005 
  • Nishimura K, Hatano Y, Setoyama T, Tsumagari H, Miyashita K, Lu S, Jisaka M, Nagaya T, and Yokota K. Control of life cycle of mouse adipogenic 3T3-L1 cells by dietary lipids and metabolic factors. Appl Biochem Biotechnol 118 (1-3) pp 97-114, 2004 
  • Nishimura K, Tsumagari H, Setoyama T, Morioka A, Lu S, Jisaka M, Nagaya T, Yokota K. Prostaglandin F(2alpha) is protective for apoptosis stimulated synergistically with 12-O-tetradecanoyl phorbol-beta-acetate and nordihydroguaiaretic acid in Madin-Darby canine kidney cells. Biochim Biophys Acta. 1682 (1-3) pp 102-11, 2004
  • Nishimura K, Tsumagari H, Morioka A, Lu S, Jisaka M, Nagaya T, Yokota K. Prostaglandin F2 protected cultured Madin-Darby canine kidney cells from the development of apoptosis induced by 12-O-tetradecanoyl phorbol-b-acetate and stimulated synergistically with nordihydroguaiaretic acid. Adv. Exp. Med.Biol. 525 pp 177-180, 2003 
  • Nishimura K, Tsumagari H, Morioka A, Yamauchi Y, Miyashita, K, Lu S, Jisaka M, Nagaya T, Yokota K. Regulation of apoptosis through the arachidonate cascade in mammalian cells. Applied Biochemistry and Biotechnology, 102-103(1-6) pp 239-250, 2002 
  • Yokota K, Lu S, Takata I, Kishimoto A, Maeta K, Nishimura K, Nagaya T,  Jisaka M. Molecular biology and biochemistry of lipoxygenases and related pathways. "New Horizons in Biotechnology", edited by S. Roussons et al., Kluwer Academic Publishers, Dordrecht, The Netherlands 


Phone: +86-025-85891620