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Shizhu Zhang Associate Professor

Research Interests: 
  • I am interested in identifying the molecular mechanisms whereby pathogenic fungi cause human disease.
  • Our work focusses on the molecular mechanisms underlying the iron homeostasis regulatory circuit in the pathogenic fungus Aspergillus fumigatus and the pathogenic adherence of fungi to host tissues.

Educational Background

PhD, College of Bioengineering, University of Chongqing, China (2007-2010)

Joint PhD, Deparment of Microbiology and Cell Science, University of Florida, USA (2008-2010)

MA, College of Bioengineering, University of Chongqing, China (2004-2007)

BA, College of life Sciences, University of LuDong, ShanDong, China (2000-2004)

Research Projects

  • The screening and function characterization of crucial iron homeostasis regulators in pathogenic fungus Aspergillus fumigatus. NSFC (NO. 31470193, 2014-2018)

Journal Articles

  • Wang, S., X. Liu, H. Qian, S. Zhang* and L. Lu* (2016). "Calcineurin and Calcium Channel CchA Coordinate the Salt Stress Response by Regulating Cytoplasmic Ca2+ Homeostasis in Aspergillus nidulans." Appl Environ Microbiol 82(11): 3420-3430. (* corresponding author)
  • Zhang, Y., Q. Zheng, C. Sun, J. Song, L. Gao, S. Zhang, A. Munoz, N. D. Read and L. Lu (2016). "Palmitoylation of the Cysteine Residue in the DHHC Motif of a Palmitoyl Transferase Mediates Ca2+ Homeostasis in Aspergillus." PLoS Genet 12(4): e1005977.
  • Zheng, H., S. Zhang, S. Zhang* and L. Lu* (2015). "Riboflavin level manipulates the successive developmental sequences in Aspergillus nidulans." Curr Microbiol 70(5): 637-642. (* corresponding author)
  • Zhang, S., H. Zheng, N. Long, N. Carbo, P. Chen, P. S. Aguilar and L. Lu (2014). "FigA, a putative homolog of low-affinity calcium system member Fig1 in Saccharomyces cerevisiae, is involved in growth and asexual and sexual development in Aspergillus nidulans." Eukaryot Cell 13(2): 295-303. 
  • Jiang, H., F. Liu, S. Zhang and L. Lu (2014). "Putative PmrA and PmcA are important for normal growth, morphogenesis and cell wall integrity, but not for viability in Aspergillus nidulans." Microbiology 160(Pt 11): 2387-2395.
  • Zhang, S., E. Widemann, G. Bernard, A. Lesot, F. Pinot, N. Pedrini and N. O. Keyhani (2012). "CYP52X1, representing new cytochrome P450 subfamily, displays fatty acid hydroxylase activity and contributes to virulence and growth on insect cuticular substrates in entomopathogenic fungus Beauveria bassiana." J Biol Chem 287(16): 13477-13486.