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Faculty

Wen Wang Professor

Research Interests: 
  • Aquatic Animal Diseases
  • Pathogen Microbiology
Bio: 

Educational Background

PhD, Ecology, Nanjing University, P.R. China, (2006)

BS, Biology, Nanjing Normal University, P.R. China, (1998)

Research Projects

  • National Natural Science Foundation of China (NSFC) (No.30371118; 30771649; 30870090; No.31170120; No.31272686).
  • Jiangsu Key Scientific Project on Key Problems (BE2007343).
  • Agricultural project in Jiangsu Province (Z200101).
  • Natural Science Foundation of Jiangsu Province (BL2000305).
  • Agricultural project in Jiangsu Province (PJ2011-65).
  • Spark Program of Chinese Ministry of Science and Technology (2011GA690157).
  • Agricultural Self-dependent Innovation Project in Jiangsu Province (CX(2)3066).
  • Jiangsu Education Department Project of Industrialization to promote Colleges and Universities in Jiangsu Province (JHB2011-19).

Journal Articles

  • Wang W. Discovery and Studies of a Novel Pathogen, Spiroplasma eriocheiris in Economically Important Species of Crustaceans (Review), J of Nanjing Normal University. 39(1): 1-13, 2016.
  • Huang Y, Hui KM, Jin M, Yin SW, Wang W*, Ren Q*, Two endoplasmic reticulum proteins (calnexin and calreticulin) are involved in innate immunity in Chinese mitten crab (Eriocheir sinensis), Scientific Reports. 6: 27578, 2016.
  • Huang Y, Wang W*, Ren Q*. Two host microRNAs influence WSSV replication via STAT gene regulation, Scientific Reports. 6: 23643, 2016.
  • Ding Z, Meng Q, Liu H, Yuan S, Zhang F, Sun M, Zhao Y, Shen M, Zhou G, Pan J, Xue H, Wang W. First case of hepatopancreatic necrosis disease in pond-reared Chinese mitten crab, Eriocheir sinensis, associated with microsporidian. J Fish Dis. 39: 1043–1051, 2016.
  • Hou L, Xiu Y, Wang J, Liu X, Liu Y, Gu W, Wang W, Meng Q. iTRAQ-based quantitative proteomic analysis of Macrobrachium rosenbergii hemocytes during Spiroplasma eriocheiris infection. J Proteomics. 136:112-22, 2016.
  • Xiu Y, Wang Y, Bi J, Liu Y, Ning M, Liu H, Li S, Gu W, Wang W, Meng Q. A novel C-type lectin is involved in the innate immunity of Macrobrachium nipponense. Fish Shellfish Immunol. 50:117-26, 2016. 
  • Huang Y, Wang W, Ren Q. Function of gC1qR in innate immunity of Chinese mitten crab, Eriocheir sinensis. Dev Comp Immunol. 61:34-41, 2016.
  • Huang Y, Jin M, Yin S, Ding Z, Wang W, Ren Q. Responses of three very large inducible GTPases to bacterial and white spot syndrome virus challenges in the giant fresh water prawn Macrobrachium rosenbergii. Fish Shellfish Immunol. 51:77-96, 2016.
  • Ding ZF, Xia SY, Xue H, Tang JQ, Ren Q, Gu W, Meng QG, Wang W. Direct visualization of the novel pathogen, Spiroplasma eriocheiris, in the freshwater crayfish Procambarus clarkii (Girard) using fluorescence in situ hybridization. J Fish Dis. 2015 Sep;38(9):787-94. 
  • Amaro F, Wang W, Gilbert JA, Anderson OR, Shuman HA. Diverse protist grazers select for virulence-related traits in Legionella. ISME J. Jul;9(7):1607-18, 2015.
  • Huang Y, Chen Y, Zhang Y, Feng J, Zhao L, Zhu H, Wang W*, Ren Q Identification, characterization, and functional studies of a Pelle gene in the Chinese mitten crab, Eriocheir sinensis. Fish Shellfish Immunol. 45:704-16, 2015. 
  • Huang Y, Zhao L, Feng J, Zhu H, Huang X, Ren Q*, Wang W**. A novel integrin function in innate immunity from Chinese mitten crab (Eriocheir sinensis). Dev Comp Immunol. 52 :155–65,2015. 
  • Huang Y, Ma F, Wang W*, Ren Q**. Identification and molecular characterization of a peritrophin-like gene, involved in the antibacterial response in Chinese mitten crab, Eriocheir sinensis. Dev Comp Immunol .50:129-138,2015.
  • Xiu Y, Wang Y, Jing Y, Qi Y, Ding Z, Meng Q**, Wang W. Molecular cloning, characterization, and expression analysis of two different types of lectins from the oriental river prawn, Macrobrachium nipponense. Fish & Shellfish Immunology. 45: 465-69, 2015.
  • Xiu Y, Hou L, Liu X, Wang Y, Gu W, Meng Q**, Wang W. Isolation and characterization of two novel C-type lectins from the oriental river prawn, Macrobrachium nipponense. Fish & Shellfish Immunology 46: 603-11,2015.
  • Hou L, Liu X, Jing Y, Zhang J, Ding Z, Huang Y, Gu W, Meng Q, Wang W. Molecular cloning and characterization of the lipopolysaccharide and -1,3-glucan binding protein from red claw crayfish, Cherax quadricarinatus. Aquaculture 441: 1–7, 2015.
  • Xiu Y, Wu T, Meng X, Meng Q, Wang W*. Identification and isolation of a spiroplasma pathogen from diseased oriental river prawn, Macrobrachium nipponense, in China: A new freshwater crustacean host. Aquaculture 437: 270-4, 2015. 
  • Huang X, Huang Y, Shi Y, Ren Q*, Wang W**. Function of a novel C-type lectin with two CRD domains from Macrobrachium rosenbergii in innate immunity. Dev Comp Immunol. 49(1):121-6, 2015.
  • Huang Y, Chen H, Wang Z, Wang W*, Ren Q*. Novel myeloid differentiation factor 88, EsMyD88, exhibits EsTube-binding activity in Chinese mitten crab Eriocheir sinensis. Dev Comp Immunol. 47:298-308, 2014. 
  • Huang Y, Huang X, Hou L, An L, Hui K, Ren Q*, Wang W* Molecular cloning and characterization of three novel Hemocyanins from Chinese mitten crab, Eriocheir sinensis. Aquaculture. 434:385-96, 2014. 
  • Huang Y, An L, Hui K, Ren Q*, Wang W* An LDLa domain-containing C-type lectin is involved in the innate immunity of Eriocheir sinensis. Dev Comp Immunol. 42: 333-44, 2014. 
  • Huang Y, Huang X, Wang Z, Tan J, Hui K, Wang W*, Ren Q* Function of two novel single-CRD containing C-type lectins in innate immunity from Eriocheir sinensis. Fish Shellfish Immunol. 37:313-21, 2014. 
  • Huang Y, Tan J, Wang Z, Yin S, Huang X, Wang W*, Ren Q*. Cloning and characterization of two different L-type lectin genes from the Chinese mitten crab Eriocheir sinensis. Dev Comp Immunol. 46: 255-66, 2014. 
  • Meng Q, Hou L, Zhao Y, Huang X, Huang Y, Xia S, Gu Wei, Wang W*. iTRAQ-based proteomic study of the effects of Spiroplasma eriocheiris on Chinese mitten crab Eriocheir sinensis hemocytes. Fish Shellfish Immunol. 40:182-9, 2014.
  • Gu W, Chen J, Hou L, Huang Y, Xia S, Meng Q*, Wang W*. The Superoxide Dismutase from Red Claw Crayfish, Cherax quadricarinatus Molecular Cloning and Characterization Analysis. Zoolog Sci. 31(11):725-34. 2014.
  • Gu W, Yao W, Zhao Y, Pei S, Jiang C, Meng Q*, Wang W*. Establishment of spiroplasma-infected hemocytes as an in vitro laboratory culture model of Chinese mitten crab Eriocheir sinensis. Vet Microbiol. 171(1-2):215-20, 2014.
  • Xiu Y, Feng J, Lu W, Liu D, Wu T, Zhu H, Liu P, Li W, Ren Q, Gu W, Meng Q*, Wang W*. Identification of a novel cognate cytosolic Hsp70 gene (MnHsc70-2) from oriental river prawn Macrobrachium nipponense and comparison of its expressions with the first cognate Hsc70 (MnHsc70-1) under different stresses. Cell Stress Chaperones. 19(6): 949-61,2014 
  • Xiu Y, Wu T, Liu P, Huang Y, Ren Q, Gu W, Meng Q*, Wang W* Molecular cloning and characterization of the lipopolysaccharide and b-1,3-glucan binding protein from oriental river prawn, Macrobrachium nipponense, Mol Biol Rep. 41:3935-44, 2014. 
  • Ding Z, Tang J, Xue H, Li J, Ren Q, Gu W, Meng Q*, Wang W*. Quantitative detection and proliferation dynamics of a novel Spiroplasma eriocheiris pathogen in the freshwater crayfish, Procambarus clarkii. J Invertebr Pathol. 115:51-4, 2014. 
  • Wu T, Ding Z, Ren M, An L, Xiao Z, Liu P, Gu W, Meng Q*, Wang W*. The histo- and ultra-pathological studies on a fatal disease of Prussian carp (Carassius gibelio) in mainland China associated with cyprinid herpesvirus 2 (CyHV-2). Aquaculture. 412-3: 8-13, 2013.
  • Huang Y, Li YR, An L, Hui KM, Ren Q, Wang W. Cloning and characterization of a clip domain serine protease and its homolog (masquerade) from Eriocheir sinensis. Fish Shellfish Immunol. 35(4):1155-62. 2013. 
  • Zhu H, Du J, Hui K, Liu P, Chen J, Xiu Y, Yao W, Wu T, Ren Q, Meng Q, Gu W, Wang W*. Diversity of lectins in Macrobrachium rosenbergii and their expression patterns under spiroplasma MR-1008 stimulation. Fish Shellfish Immunol. 2013. 35(2): 300-9, 2013. 
  • Hui K, Hao F, Li W, Zhang Z, Zhang CY, Wang W*, Ren Q*. Cloning and identification of four Mu-type glutathione S-transferases from the giant freshwater prawn Macrobrachium rosenbergii. Fish Shellfish Immunol. 35(2):546-52, 2013. 
  • Ou J, Li Y, Ding Z, Xiu Y, Wu T, Du J, Li W, Zhu H, Ren Q, Gu W, Wang W* Transcriptome-wide identification and characterization of the Procambarus clarkii microRNAs potentially related to immunity against Spiroplasma eriocheiris infection. Fish Shellfish Immunol. 35(2): 607-17, 2013. 
  • Meng Q, Chen J, Xu C, Huang Y, Wang Y, Wang T , Zhai X, Gu W, Wang W* The characterization, expression and activity 1 analysis of superoxide 2 dismutases (SODs) from Procambarus clarkii. Aquaculture, 406-407:131-40, 2013.
  • Ding Z, Yao W, Du J, Ren Q, Li W, Wu T, Xiu Y, Meng Q, Gu W, Xue H, Tang J, Wang W*, Histopathological characterization and in situ hybridization of a novel spiroplasma pathogen in the freshwater crayfish Procambarus clarkii. Aquaculture. 380-3:106-113, 2013.
  • Ren Q*, Zhong X, Yin S, Hao F, Hui K, Zhang Z, Zhang C, Yu X, Wang W*, The first Toll receptor from the triangle-shell pearl mussel Hyriopsis cumingii, Fish Shellfish Immunol, 34(5):1287-93. 2013.
  • Xiu Y, Wu T, Du J, Yao W, Li W, Ding Z, Ren Q, Gu W, Meng Q*,Wang W*. Molecular characterization and expression analysis 1 of extracellular copper/zinc superoxide dismutase (ecCuZnSOD) from oriental river prawn, Macrobrachium nipponense. Aquaculture. 380-383:23-8, 2013. 
  • Du J, Zhu H, Liu P, Chen J, Xiu Y, Yao W, Wu T, Ren Q, Meng Q, Gu W, Wang W*. Immune responses and gene expression in hepatopancreas from Macrobrachium rosenbergii challenged by a novel pathogen spiroplasma MR-1008. Fish Shellfish Immunol.. 34(1):315-23, 2013. 
  • Du J, Zhu H, Ren Q, Liu P, Chen J, Xiu Y, Yao W, Meng Q, Gu W, Wang W*. Flow cytometry studies on the Macrobrachium rosenbergii hemocytes sub-populations and immune responses to novel pathogen spiroplasma MR-1008. Fish Shellfish Immunol. 33(4):795-800, 2012.
  • Ren Q*, Qi YL, Hui KM, Zhang Z, Zhang CY, Wang W.* Four invertebrate-type lysozyme genes from triangle-shell pearl mussel (Hyriopsis cumingii). Fish Shellfish Immunol 33(4):909-915, 2012. 
  • Ren Q*, Zhang Z, Li XC, Jie-Du, Hui KM, Zhang CY, Wang W*. Three different anti-lipopolysaccharide factors identified from giant freshwater prawn, Macrobrachium rosenbergii. Fish Shellfish Immunol. 33(4):766-77, 2012.
  • Liang T, Ji H, Du J, Ou J, Li W, Wu T, Meng Q, Gu W, Wang W*. Primary culture of hemocytes from Eriocheir sinensis and their immune effects to the novel crustacean pathogen Spiroplasma eriocheiris. Molecular Biology Report. 39(10):9747-54, 2012. 
  • Ding Z, Du J, Ou J, Li W, Wu T, Xiu Y, Meng Q, Wu W, Xue H, Tang J, Wang W*. Classification of circulating hemocytes from the red swamp crayfish Procambarus clarkii and their susceptibility to the novel pathogen Spiroplasma eriocheiris in vitro. Aquaculture. 356-7:371-380, 2012.
  • Ren Q*, Li M, Du J, Zhang CY, Wang W*. Immune response of four dual-CRD C-type lectins to microbial challenges in giant freshwater prawn Macrobrachium rosenbergii. Fish Shellfish Immunol..33(2):155-67, 2012.
  • Ou J, Meng Q, Li Y, Xiu Y, Du J, Gu W, Wu T, Li W, Ding Z, Wang W*. Identification and comparative analysis of the Eriocheir sinensis microRNA transcriptome response to Spiroplasma infection using a deep sequencing approach. Fish Shellfish Immunol. 32:345-52, 2012.
  • Du J, Ou J, Li W, Ding Z, Wu T, Meng Q, Gu W, Wang W*. Primary hemocytes culture of the freshwater prawn Macrobrachium rosenbergii and their susceptibility to the novel pathogen spiroplasma strain MR-1008. Aquaculture. 330-3: 21-8, 2012. 
  • Liang T, Wu T, Du J, Ji H, Li Y, Gu W, Wang W* Characterization of a tailless white spot syndrome virus from diseased Penaeus vannamei and Procambarus clarkii in China. Afr J Biotechnol. 10:13936-42, 2011. 
  • Anderson OR, Wang W, Faucher SP, Bi Keran, Shuman HA. A New Heterolobosean Amoeba Solumitrus palustris n. g., n. sp. Isolated from Freshwater Marsh Soil. J Eukaryot Microbiol. 58: 60–7, 2011. 
  • Meng Q, Du Jie, Yao W, Xiu Y, Li Y, Gu W, Wang W* An extracellular copper/zinc superoxide dismutase (ecCuZnSOD) from Chinese mitten crab, Eriocheir sinensis and its relationship with Spiroplasma eriocheiris.  Aquaculture. 320:56-61, 2011. 
  • Liang T, Li X, Du Jie, Yao W, Sun G, Dong X, Liu Z, Ou J, Meng Q, Gu W, Wang W* Identification and isolation of a spiroplasma pathogen from diseased freshwater prawns, Macrobrachium rosenbergii, in China: A new freshwater crustacean host. Aquaculture. 318: 1-6, 2011. 
  • Wang W*, Gu W. Gasparich GE. Bi K, Ou J, Meng Q, Liang T, Feng Q, Zhang J, Zhang Y. Spiroplasma eriocheiris sp. nov., a novel species associated with mortalities in Eriocheir sinensis, Chinese mitten crab. Int J Syst Evol Microbiol. 61:2745-52, 2011. 
  • Feng Q, Wu G, Liang T, Ji H, Jiang X, Gu W, Wang W*. Pharmacokinetics of oxytetracycline in hemolymph from the Chinese mitten crab, Eriocheir sinensis. J Vet Pharmacol Therap. 34:51-7, 2011. 
  • Wang W*. Bacterial diseases of crabs: A review J Invertebr Pathol. 106:18-26, 2011. 
  • Meng Q, Li W, Liang T, Jiang X, Gu W, Wang W*. Identification of adhesin-like protein ALP41 from Spiroplasma eriocheiris and induction immune response of Eriocheir sinensis. Fish Shellfish Immunol. 29:587-593, 2010.
  • Meng Q, Ou J, Ji H, Jiang X, Gu W, Wang W*. Identification and characterization of spiralin-like protein SLP25 from Spiroplasma eriocheiris. Vet Microbiol. 4:473-7, 2010. 
  • Feng Q, Gao T, Ji H, Jiang X, Liang T, Gu W, Wu G, Gao G, Wang W*. Kinetic analysis of oxytetracycline residues in Chinese mitten crab, Eriocheir sinensis, muscle following intramuscular administration. J Fish Dis. 33: 639-47, 2010.
  • Liang T, Ji H, Lian L, Wu T, Gu W, Wang W*. A rapid assay for simultaneous detection of Spiroplasma eriocheiris and white spot syndrome virus in Procambarus clarkii by multiplex PCR. Lett Appl Microbiol. 51:532-38, 2010.
  • Meng Q, Ji H, Bi K, Jiang X, Gu W, Wang W*. Spiralin-like protein SLP31 from Spiroplasma eriocheiris as a potential antigen for immunodiagnostics of tremor disease in Chinese mitten crab Eriocheir sinensis. Folia Microbiol. 55:245-50, 2010.
  • Liang T, Feng Q, Wu T, Gu W, Wang W*. Use of oxytetracycline for the treatment of tremor disease in the Chinese mitten crab Eriocheir sinensis Dis Aquat Organ, 84:243-50, 2009. 
  • Wang J, Huang H, Feng Q, Liang T, Bi K, Gu W, Wang W*. Enzyme-lined immunosorbent assay for the detection of pathogenic spiroplasma in commercially exploited crustaceans from China. Aquaculture. 92:166-71, 2009.
  • Bi K, Huang H, Gu W, Wang J, Wang W*. Phylogenetic analysis of Spiroplasmas from three freshwater crustaceans (Eriocheir sinensis, Procambarus clarkia and Penaeus vannamei) in China. J Invertebr Pathol. 99:57-65, 2008. 
  • Bi K, Gu W, Wang W*. Sensitive and rapid detection of freshwater crustacean Spiroplasmas by ISRs-sequence-targeted species-specific primers. Eur Food Res Technol. 227:1733-7, 2008.
  • Ding Z, Bi K, Wu T, Gu W, Wang W*, Chen J. A simple PCR method for the detection of pathogenic spiroplasmas in crustaceans and environmental samples. Aquaculture. 265: 49–54, 2007. 
  • Wang W*, Chen J. Ultrastructural study on a novel microsporidian, Endoreticulatus eriocheir sp. nov (Microsporidia, Encephalitozoonidae), parasite of Chinese mitten crab, Eriocheir sinensis (Crustacea, Decapoda). J Invertebr Pathol. 94:77–83, 2007. 
  • Wang W*, Gu W, Ding Z, Ren Y, Chen J, Hou Y. A novel Spiroplasma Pathogen Causing Systemic Infection in the Crayfish Procambarus Clarkii (Crustacea:Decapod), in China. FEMS Microbiol Lett. 249(1): 131-7, 2005. 
  • Wang W*, Wen B, Gasparich GE, Zhu N, Rong L, Chen J, Xu Z. A spiroplasma associated with tremor disease in the Chinese mitten crab (Eriocheir sinensis). Microbiology.150: 3035-40, 2004. 
  • Wang W*, Chen J, Du K, Xu Z. Morphology of spiroplasmas in the Chinese mitten crab Eriocheir sinensis associated with tremor disease. Res Microbiol. 155(8): 630-5, 2004. 
  • Wang W*, Rong L, Gu W, Du K, Chen J. Study on experimental infections of TDA from the Chinese mitten crab in crayfish, mice and embryonated chickens. Res Microbiol. 154(10): 677-80, 2003.
  • Wang W*, Gu Z. Rickettsia-like Organism Associated with Tremor Disease and Mortality of the Chinese Mitten Crab, Eriocheir sinensis. Dis Aquat Organ. 48(2): 149-53,2002.
  • Wang W*, Zhu N, Gu Z, Du K, Xu Z. Study on the Transmission of Tremor Disease (TD) in the Chinese Mitten Crab, Eriocheir sinensis (Crustacea: Decapoda). J Invertebr Pathol. 81(3): 202-4, 2002. 

 
Patents

Wang W, Ding Z, Gu W. The rapid PCR technique for testing spiroplasma pathogen (ZL 2005 1 0041005.x) 

Wang W, Wang J, Huang H, Gu W, Wu T. An enzyme linked immunosorbent assay kit for detecting spiroplasma pathogen from aquatic animals (ZL 2007 1 0025337.8).

Wang W, Gu W, Bi K, Huang H, Wang J. A bacterial strain of spiroplasma and its applications.

Wang W, Liang T, Gu W, Feng Q. Application of terramycin for treating the diseases caused by spiorplasma pathogen of aquatic animals.

Wang W, Ding ZF, Meng Q, Gu W, Ren Q. Probes of hybridization in situ and assay kit for detecting sprioplasmas from aquatic crustaceans. (ZL 2012 1 00443870.7).

Honors and Awards

The second prize of Chinese agricultural science and technology awarded by The Ministry of Agriculture of the Peoples’s Republic of China (MOA), 2015.

The first prize of Scientific and Technical Academy Awards of Jiangsu province, 2014.

The second prize of Ministry of Education of the People’s Republic of China

Academic Title

Standing Director of Asian Organization for Mycoplasmology (AOM)

Editorial Board Member of Journal of Nanjing Normal University (Engineering)

Contact

Phone: +86-25-85891955(O)

E-mails:wenwang@njnu.edu.cn;  njnuwang@263.net