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Faculty

Yuqing Chen Associate Professor

Research Interests: 
  • Anticancer mechanism of antimicrobial peptides
  • Modification of antimicrobial peptides and their activities
  • Immunological molecules of animal in wildlife protection and health
Bio: 

Educational Background

PhD. in Zoology, College of Life Sciences, Nanjing Normal University (2008)

MA, College of Agronomy, Sichuan Agricultural University (2000)

BA, College of Agronomy, Sichuan Agricultural University (1997)

Research Projects

  • 2016,1-2019,12 Study on the molecular mechanism of cancer-selective toxicity of N-acylated antimicrobial peptide CM4, National Natural Science Foundation of China (Grant No. 81573337)  Principal Investigator
  • 2014,7-2017,6 The anticancer activity and molecular mechanism of myristoylated CM4, Natural Science Foundation of Jiangsu Province of China (Grant No. BK20141446)  Principal Investigator
  • 2010,1-2012,12 The mechanism of selectivity between normal cells and cancer cells of anticancer peptide CM4, National Natural Science Foundation of China (Grant No. 30900743) Principal Investigator
  • 2008.09-2010.12 Construction of difunctional fused protein ABP:sTRAIL and its anticancer activity, the Natural Science Foundation of Jiangsu Higher Education Institutions of China (GrantNo. 08KJB180006)  Principal Investigator

Journal Articles

  • Shi W, Li CY, Li M, Zong XC, Han DJ, Chen YQ*. Antimicrobial peptide melittin against Xanthomonas oryzae pv. oryzae, the bacterial leaf blight pathogen in rice. Applied Microbiology and Biotechnology. 2016, 100(11), 5059-5067   (SCI , corresponding author)
  • Sang M, Zhang JX, Li B, Chen YQ*. TRAIL-CM4 fusion protein shows in vitro antibacterial activity and a stronger antitumor activity than solo TRAIL protein. Protein Expression and Purification. 2016, 122:82-89  (SCI , corresponding author)
  • Shi W, li CY, Chen YQ*. The effect of melittin on rat red blood cells and its mechanism. Journal of Nnajing Normal University (Natural Science). 2015, 38(2): 86-92  (corresponding author)
  • Han YY, Liu HY, Han DJ, Zong XC, Zhang SQ, Chen YQ*. Role of glycosylation in the anticancer activity of antibacterial peptides against breast cancer cells. Biochemical Pharmacology. 2013, 86(9): 1254–1262  (SCI , corresponding author)
  • Liu HY, Han YY, Fu HY, Liu M, Wu J, Chen XN, Zhang SQ, Chen YQ*. Construction and expression of sTRAIL–melittin combining enhanced anticancer activity with antibacterial activity in Escherichia coli. Applied Microbiology and Biotechnology. 2013, 97(7):2877-2884   (SCI , corresponding author)
  • Min C, Wang Q, Chen YQ*, Zhang SQ, Yao ZG, Ding YH, Ren YJ. cDNA cloning and recombinant expression of a proliferation inducing ligand (APRIL) from Père David’s deer. Research in Veterinary Science. 2012, 92:240–242  (SCI , corresponding author)
  • Min C, Han YY, Liu HY, Chen YQ*, Zhang SQ, Yao ZG, Ding YH. cDNA cloning, recombinant expression and bioactivity of Père David's deer BAFF. Gene. 2012, 505(2):233-239.   (SCI , corresponding author)
  • Min C, Liang ZN, Cui XW, Wang Q, Chen YQ*, Zhang SQ*. Molecular cloning and partial functional characterization of a proliferation inducing ligand (APRIL) in zebrafish (Danio rerio). Developmental and Comparative Immunology. 2012, 37(1):202-206 (SCI , corresponding author)
  • Li JF, Zhang J, Xu XZ, Han YY. Cui XW, Chen YQ, Zhang SQ*. The antibacterial peptide ABP-CM4: the current state of its production and applications. Amino Acids. 2012, 42:2393–2402   (SCI )
  • Shen YF, Wang SL, Ai HX, Min C, Chen YQ*, Zhang SQ*.  Molecular structure, bioinformatics analysis, expression and bioactivity of BAFF (TNF13B) in dog (Canis familiaris). Veterinary Immunology and Immunopathology. 2011, 142:133–139   (SCI , corresponding author)
  • Chen YQ*, Min C, Sang M, Han YY, Ma X, Xue XQ, Zhang SQ. A cationic amphiphilic peptide ABP-CM4 exhibits selective cytotoxicity against leukemia cells. Peptides. 2010, 31:1504–1510  (SCI , corresponding author)
  • Chen YQ, Ren GJ, An SQ*, Sun QY, Liu CH and Shuang JL.  Bacterial community changes after the colonization of Phragmites in copper mine tailings. Pedosphere. 2008, 18(6): 731-740 (SCI)
  • Chen YQ, Zhang SQ*, Li BC, Qiu W, Jiao B, Zhang J, Diao ZY. Expression of a cytotoxic cationic antibacterial peptide in Escherichia coli using two fusion partners. Protein Expression and Purification. 2008,57:303-311   (SCI)
  • Chen YQ, Li BC, Wu X, Zhang SQ*. The isolation and identification of the antibacterial peptide cecropin D and lysozyme from Chinese domestic silkworm larvae, Bombyx mori. Journal of Nnajing Normal University (Natural Science). 2006, 29(3):103-107
  • Lin QP, Zhou LF, Li NN, Chen YQ, Li BC, Cai YF, Zhang SQ. Lipopolysaccharide neutralization by the antibacterial peptide CM4. European Journal of Pharmacology. 2008, 596: 160-165, 2008  (SCI)
  • Li BC, Zhang SQ, Dan WB, Chen YQ , Cao P. Expression in Escherichia coli and purification of bioactive antibacterial peptide ABP-CM4 from the Chinese silk worm, Bombyx mori. Biotechnology Letters. 2007, 29(7):1031-1036   (SCI)
  • Zhang J, Zhang SQ*, Wu X, Chen YQ, Diao ZY. Expression and characterization of antimicrobial peptide ABP-CM4 in methylotrophic yeast Pichia pastoris. Process Biochemistry. 2006, 41: 251–256  (SCI)
  • Chen YQ, Wen SQ, Zhang SQ. Advance in selective action in peptide antibiotics on cells. Chinese Journal of Antibiotics. 2006,5(31): 257-260 
  • Chen YQ, Zheng YL, Liu DC. Genetic diversity of Sichuan wheat cultivars based on quantitative morphological traits. Southwest China Journal of Agricultural Sciences. 2002, 15(2): 1-4 
  • Chen YQ, Zheng YL, Zhou YH. Genetic diversity of Sichuan wheat germplasm based on coeff icient of parentage. Journal of Nnajing Normal University (Natural Science). 2002, 25(2): 22-27 
  • Zhen YL, Chen YQ, Wei YM, Zhou YH, Zhang ZQ, Liu DC. Esterase, gliadins and RAPD variations among Sichuan wheat cultivars. Wheat Information Service (WIS) .2001,92: 5-8

Contact

Tel: +86-13645197488

E-mail: chenyuqing@njnu.edu.cn