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Faculty

Zhigang Guo Professor

Research Interests: 
  • DNA Repair and Cancer Research
  • Antibody Engineering & therapeutic antibody
Bio: 

Educational Background

Nanjing University  Ph.D Biochemistry & Molecular Biology  2001- 2005

Yangzhou University  M.S  Biochemistry & Molecular Biology 1998- 2001

Jiangxi Agriculture University  B.S Biology  1994-1998

Nanjing Normal University, Professor, College of Life Science 2011.3~ Present

National Medical Center & Beckman Research Institute, City of Hope Research Fellow/Staff Scientist 2006. 9~ 2011.3

Tanox /Genentech 2005 .5~ 2006.9

​Membership

American Association for Cancer Research (AACR) 

American Association for the Advancement of Science (AAAS)

American Society for Biochemistry and Molecular Biology (ASBMB)

Sigma Xi, the Scientific Research Society

Grant

  • National Key Basic Research Program of China for young scientists (2013CB911600, 5 Million RMB)
  • The General Program of National Natural Science Foundation of China (31271449, 800K RMB)
  • Jiangsu Province Natural Science Funds for Distinguished Young Scholar (BK20130044, 1 Million RMB), 
  • The State Key Program of Jiangsu Province Natural Science Foundation (BK20130061, 1 Million RMB)
  • Research Fund for the Doctoral Program of Higher Education of China (RFDP) (20133207110005 150K RMB)
  • Program for New Century Excellent Talents in University of Ministry of Education of China (NCET-13-0868, 500K RMB)
  • Jiangsu Province Natural Science Foundation Projects (BK2011783, 100K RMB)  

Journal Articles

  • Hongfang Sun, Xuping Wu, Ting Zhou, Jing Zhao, , Xiao Lou, Sencai Hu, Pan Feiyan, Chengzhongqin, Lingfeng He, Zhigang Guo(通讯作者)**. A novel strategy to impede cancer progression by inhibiting DNA Flap Endonuclease 1. eBiomedicine (2016) Revision.
  • Zhou X, Zhuang Z, Wang W, He L, Wu H, Cao Y, Pan F, Zhao J, Hu Z, Sekhar C, Zhigang Guo *. OGG1 is essential in oxidative stress induced DNA demethylation. Cell Signal. 2016 Sep;28(9):1163-71. doi: 10.1016/j.cellsig.2016.05.021. Epub 2016 May 29. 
  • Hu Zhigang*, Li Jiaxin, Kuang Zhihui, Wang Meina, Azhar Salman, and Zhigang Guo *.  Polymorphism and Hormonal Regulation of DNA Methylation in Scavenger Receptor Class B, Type I. DNA and Cell Biology. June 2016, 35(6): 280-289. doi:10.1089/dna.2015.3185.  
  • Cao Y, Yang H, Zhou X, Mao H, Gao T, Hu Z, He L, Pan F, Guo Z. Selection and characterization of human PCSK9 antibody from phage displayed antibody library. Biochem Biophys Res Commun. 2015 Aug 7;463(4):712-8. (citation 1)
  • Bing Lü, ZhiGang Guo, JianSheng Liang. Effects of the activities of key enzymes involved in starch biosynthesis on the fine structure of amylopectin in developing rice (Oryza sativa L.) endosperms. Sci China C Life Sci. (2008 ) 51(10):863-71 
  • Guo Z1, Bi F, Tang Y, Zhang J, Yuan D, Xia Z, Liu JN. Preparation and characterization of scFv for affinity purification of reteplase. J Biochem Biophys Methods. 2006 Apr 30;67(1):27-36. Epub 2006 Feb 10.
  • Chen Qian Jian-Ning Liu Fengyuan Tang Dawen Yuan Zhigang Guo and Jing Zhang.  A Novel Strategy for Proteome-wide Ligand Screening Using Cross-linked Phage Matrices. Journal of Biological Chemistry (2008) 285,9367-9372.
  • Ying-Jiang Zhou, Shi-Quan Wang, Jing Zhang, Wei Zhang, Feng Bi, Zhi-Gang Guo, Bi-Sen Ding, Pat Kumar, Jian-Ning Liu, Xiang-Yang Tan A novel method to isolate and map endothelial membrane proteins from pulmonary vasculature. American Journal of Physiology - Cell Physiology ( 2005) 288(4) C950-C956  
  • Wei Zhang, Ying-Jiang Zhou, Zhi-Gang Guo, Feng Bi, Jing Zhang, Pat Kumar, Xiang-Yang Tan, and Jian-Ning Liu. Preparation of Tissue-Specific Monoclonal Antibodies Using Purified Endothelial Membrane Proteins from Biotinylated Pulmonary Vasculature of Rhesus Monkey. Hybridoma (2006), 25(1): 15-19. 

Contact

E-mail: guozgang@gmail.com; guo@njnu.edu.cn