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Faculty

Zhigang Hu Associate Professor

Academic Area: 
Cellular Biology
Bio: 

Educational Background

Sep. 1999-Jun. 2003: Jiangsu University, Zhenjiang, Jinagsu, P.R. China, B.S.

Sep. 2003-Jun. 2006: Jiangsu University, Zhenjiang, Jiangsu, P.R. China M.S.

Molecular Biology and Biochemistry

Feb. 2007-Aug. 2009: Dong-A University, Busan, Republic of Korea, Ph.D. Medical bioscience

Jan.2010-Nov.2013: Stanford University Medicine School, Palo Alto, USA.

Postdoctoral Fellow. Steroidogenesis and lipogenesis

Research Projects

  • Natural Science Fund of Colleges and Universities in Jiangsu Province(2014.07-2016.12)
  • National Natural Science Foundation of China (2015.01-2017.12)
  • Jiangsu Provincial Natural Science Foundation (2014.07-2017.06)
  • Scientific Research Foundation for the Returned Overseas Chinese Scholars(2014.07-2017.6)

Journal Articles

  • Pan F, Zhao J, Zhou T, Kuang Z, Dai H, Wu H, Sun H, Zhou X, Wu X, Hu Z, He L, Shen B, Guo Z. Mutation of DNA Polymerase β R137Q Results in Retarded Embryo Development Due to Impaired DNA Base Excision Repair in Mice. Sci Rep. 2016, 6:28614.
  • Sun H, He L, Wu H, Pan F, Wu X, Zhao J, Hu Z, Sekhar C, Li H, Zheng L, Chen H, Shen BH, Guo Z. The FEN1 L209P mutation interferes with long-patch base excision repair and induces cellular transformation[J]. Oncogene, 2016.
  • Hu Z, Li J, Kuang Z, et al. Cell-Specific Polymorphism and Hormonal Regulation of DNA Methylation in Scavenger Receptor Class B, Type I[J]. DNA and cell biology, 2016, 35(6): 280-289.
  • Zhou X, Zhuang Z, Wang W, He L, Wu H, Cao Y, Pan F, Zhao J, Hu Z, Sekhar C, Guo Z. OGG1 is essential in oxidative stress induced DNA demethylation. Cell Signal. 2016, 28(9):1163-1171.
  • Shen W J, Hu Z, Hu J, et al. Post-transcriptional and Post-translational Regulation of Steroidogenesis[M]//Post-transcriptional Mechanisms in Endocrine Regulation. Springer International Publishing, 2016: 253-275.
  • Zhou T, Pan F, Cao Y, Han Y, Zhao J, Sun H, Zhou X, Wu X, He L, Hu Z, Chen H, Shen B, Guo Z.. R152C DNA Pol β mutation impairs base excision repair and induces cellular transformation. Oncotarget, 2016, 7(6): 6902.
  • Hu Z, Hu J, Shen W J, et al. A Novel Role of Salt-Inducible Kinase 1 (SIK1) in the Post-Translational Regulation of Scavenger Receptor Class B Type 1 Activity. Biochemistry, 2015, 54(46):6917-30.
  • Cao Y, .. Hu Z.., Guo Z. Selection and characterization of human PCSK9 antibody from phage displayed antibody library[J]. Biochemical and biophysical research communications, 2015, 463(4): 712-718.
  • Shen W J, Hu J, Hu Z, et al. Scavenger receptor class B type I (SR-BI): a versatile receptor with multiple functions and actions[J]. Metabolism, 2014, 63(7): 875-886.
  • Hu Z, Shen W J, Cortez Y, et al. Hormonal regulation of microRNA expression in steroid producing cells of the ovary, testis and adrenal gland[J]. PloS one, 2013, 8(10): e78040-e78040.
  • Hu, Z., Hu, J., Zhang, Z., Shen, W. J., Yun, C. C., Berlot, C. H., ... & Azhar, S. (2013). Regulation of Expression and Function of Scavenger Receptor Class B, Type I (SR-BI) by Na+/H+ Exchanger Regulatory Factors (NHERFs). Journal of Biological Chemistry, 288(16), 11416-11435.
  • Hu, Z, et al. MicroRNAs 125a and 455 Repress Lipoprotein-Supported Steroidogenesis by Targeting Scavenger Receptor Class B Type I in Steroidogenic Cells. Molecular and Cellular Biology, 2012, 32(24): 5035-5045.
  • Hu Z., Lee K.S., et al. Molecular characterization of 1-Cys and 2-Cys peroxiredoxins from the bumblebee Bombus ignitus. Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, 2010, 155(3): 272-280
  • Hu Z. et al. Molecular characterization of a phospholipid hydroperoxide glutathione peroxidase from the bumblebee Bombus ignitus. Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, 2010, 155(1): 54-61
  • Xin Y., Choo Y.M., Hu Z., et al. Molecular cloning and characterization of a venom phospholipase A(2) from the bumblebee Bombus ignitus. Comp Biochem Physiol B Biochem Mol Biol. 2009, 154(2): 195-202.
  • Hu Z., & Sohn, H. D. (2009). Molecular Cloning and Characterization of a Lipocalin in the Bumblebee Bombus Ignitus. International Journal of Industrial Entomology, 19(2), 229-235.
  • Hu Z., et al. Molecular Cloning and Characterization of a Muscle-Specific Lipase from the Bumblebee Bombus ignitus. International Journal of Industrial Entomology, 2008, 17(1): 143-151.
  • Zhao Y., Yao Q., Tang Xu., Wang Q., Hu Z., et al. Cloning and homologic analysis of Tpn I gene in silkworm bombyx mori, African Journal of Biotechnology, 2007, 6(6): 672-676.
  • Hu Z., et al. Cloning and Characterization of Bombyx mori PP-BP a Gene Induced by Viral Infection, Acta Genetica Sinica, 2006, 33(11): 975-983.
  • Hu Z., Chen K., Gao L., Yao Q. RNA Interference to Prevent Bombyx mori Nuclear Polyhedrosis Virus Infection in Vivo, IJIE, 2006, 12(1):15-19.
  • Yao Q., Gao L., Chen K., Hu Z. Detection of proliferation of Bombyx mori nucleopolyhedrovirus in its host by fluorescence quantitative PCR. Acta entomological sinica. 2005, 48(6): 871-875. In Chinese.
  • Hu Z. et al. Identification and characterization of Bombyx mori eIF5A gene through bioinformatics approaches, In Silico Biology, 2005, 5: 0051.
  • Yao Q., Hu Z., Chen K. Cloning and Characterization of Ribosome-associated Membrane Protein 4 (RAMP4) gene in silkworm Bombyx mori, International Journal of Industrial Entomology, 2005, 10(2):125-129.

Contact

Tel: +8613814007806

E-mail: huzg_2000@126.com