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Faculty

Zhimin Yin Professor

Research Interests: 
  • Inflammation and Drug targets
  • Cancer biomarker discovery and cancer biology
  • Amino acid fermentation
Bio: 

Educational Background

1995 Ph. D. Medical University of Luebeck, Germany(major in Biochemistry)

1986 M. Sc. Nanjing University, China (major in plant)

1982 B. SC. Nanjing University, China (major in plant)

Research Projects
 

  • The molecular mechanism of HSP27 regulating LPS induced monocytes activation through binding with p53.  National Nature Science Foundation 2013-2016

  • The molecular mechanism of GSTp phosphorylation and nuclear tranlocation inhibits LPS induced HMGB1 release.  National Nature Science Foundation 2015-2018
  • The study of key technologies in  L-theanine  industrial production.  Jiangsu perspective study 2013-2016

Journal Articles

  • Cao X, Kong X, Zhou Y, Lan L, Luo L, Yin Z*(*Corresponding author)., Glutathione S-transferase P1 suppresses iNOS protein stability in RAW264.7 macrophage-like cells after LPS stimulation. Free Radic Res. 2015;49(12):1438-1448. 
  • Ruan J, Qi Z, Shen L, Jiang Y, Xu Y, Lan L, Luo L, Yin Z.* (*Corresponding author), Crosstalk between JNK and NF-κB signaling pathways via HSP27 phosphorylation in HepG2 cells. Biochem Biophys Res Commun. 2015;456(1):122-128. 
  • Fan Y, Zhang J, Cai L, Wang S, Liu C, Zhang Y, You L, Fu Y, Shi Z, Yin Z, Luo L, Chang Y, Duan X. The effect of anti-inflammatory properties of ferritin light chain on lipopolysaccharide-induced inflammatory response in murine macrophages.Biochim Biophys Acta. 2014;1843(11):2775-2783.
  • Pan X, Cao X, Li N, Xu Y, Wu Q, Bai J, Yin Z.* (*Corresponding author), Luo L, Lan L. Forsythin inhibits lipopolysaccharide-induced inflammation by suppressing JAK-STAT and p38 MAPK signalings and ROS production.Inflamm Res. 2014;63(7):597-608. 
  • Qi Z, Shen L, Zhou H, Jiang Y, Lan L, Luo L, Yin Z*(*Corresponding author). Phosphorylation of heat shock protein 27 antagonizes TNF-α induced HeLa cell apoptosis via regulating TAK1 ubiquitination and activation of p38 and ERK signaling.Cell Signal. 2014;26(7):1616-1625. 
  • Hong Z, Cao X, Li N, Zhang Y, Lan L, Zhou Y, Pan X, Shen L, Yin Z*(*Corresponding author), Luo L. Luteolin is effective in the non-small cell lung cancer model with L858R/T790M EGF receptor mutation and erlotinib resistance.Br J Pharmacol 2014;171(11):2842-2853. 
  • Chen D, Liu J, Rui B, Gao M, Zhao N, Sun S, Bi A, Yang T, Guo Y, Yin Z*(*Corresponding author), Luo L. GSTpi protects against angiotensin II-induced proliferation and migration of vascular smooth muscle cells by preventing signal transducer and activator of transcription 3 activation.Biochim Biophys Acta. 2014;1843(2):454-463
  • Chen D, Bi A, Dong X, Jiang Y, Rui B, Liu J, Yin Z*(*Corresponding author), Luo L, Luteolin exhibits anti-inflammatory effects by blocking the activity of heat shock protein 90 in macrophages.Biochem Biophys Res Commun. 2014;443(1):326-332. 
  • Qi S, Xin Y, Qi Z, Xu Y, Diao Y, Lan L, Luo L, Yin Z*(*Corresponding author).HSP27 phosphorylation modulates TRAIL-induced activation of Src-Akt/ERK signaling through interaction with β-arrestin2.Cell Signal. 2014;26(3):594-602.
  • Diao Y, Xin Y, Zhou Y, Li N, Pan X, Qi S, Qi Z, Xu Y, Luo L, Wan H, Lan L, Yin Z*(*Corresponding author). Extracellular polysaccharide from Bacillus sp. strain LBP32 prevents LPS-induced inflammation in RAW 264.7 macrophages by inhibiting NF-κB and MAPKs activation and ROS production. Int Immunopharmacol. 2014;18(1):12-19 
  • Xin Y, Yin F, Qi S, Shen L, Xu Y, Luo L, Lan L, Yin Z*(*Corresponding author). Parthenolide reverses doxorubicin resistance in human lung carcinoma A549 cells by attenuating NF-κB activation and HSP70 up-regulation.Toxicol Lett. 2013;221(2):73-82. 
  • Qi Z, Yin F, Lu L, Shen L, Qi S, Lan L, Luo L, Yin Z*(*Corresponding author). Baicalein reduces lipopolysaccharide-induced inflammation via suppressing JAK/STATs activation and ROS production.Inflamm Res. 2013;62(9):845-855. 
  • 13.Xu Y, Diao Y, Qi S, Pan X, Wang Q, Xin Y, Cao X, Ruan J, Zhao Z, Luo L, Liu C, Yin Z*(*Corresponding author). Phosphorylated Hsp27 activates ATM-dependent p53 signaling and mediates the resistance of MCF-7 cells to doxorubicin-induced apoptosis.Cell Signal. 2013;25(5):1176-1185. 
  • Cao X, Yue L, Song J, Wu Q, Li N, Luo L, Lan L, Yin Z*. Inducible HSP70 antagonizes IL-1β cytocidal effects through inhibiting NF-kB activation via destabilizing TAK1 in HeLa cells. PLoS One.7(11):e50059,2012(*Corresponding author).
  • Li G, Ye Y, Kang J, Yao X, Zhang Y, Jiang W, Gao M, Dai Y, Xin Y, Wang Q, Yin Z*, Luo L l-Theanine prevents alcoholic liver injury through enhancing the antioxidant capability of hepatocytes.Food Chem Toxicol. 50(2):14.363-372,2011 (*Corresponding author).
  • Kou X, Qi S, Dai W, Luo L, Yin Z*(*Corresponding author)..Arctigenin inhibits lipopolysaccharide-induced iNOS expression in RAW264.7 cells through suppressing JAK-STAT signal pathway.Int Immunopharmacol11(8):1095-102.2011 
  • Yimiao Xu, Yinqiang Xin., Ying Diao, Changyan Lu, Jin Fu, Lan Luo, Zhimin Yin*. Synergistic Effects of Apigenin and Paclitaxel on Apoptosis of Cancer Cells     PLoS ONE, Volume 6 | Issue 12 |e29169. 2011(*Corresponding author).
  • Wang Q, Zhu F, Xin Y, Liu J, Luo L, Yin Z* .Expression and purification of antimicrobial peptide buforin IIb in Escherichia coli.Biotechnol Lett. 33(11):2121-6. 2011(*Corresponding author)
  • Qian J, Jiang F, Wang B, Yu Y, Zhang X, Yin Z, Liu C.Ophiopogonin D prevents H2O2-induced injury in primary human umbilical vein endothelial cells.J Ethnopharmacol. Mar 24;128(2):438-45. 2010
  • Xu Y, Chen J, Yu X, Tao W, Jiang F, Yin Z, Liu C.Protective effects of chlorogenic acid on acute hepatotoxicity induced by lipopolysaccharide in mice.Inflamm Res. (10):871-7. 2010
  • Shimei Qi, Yinqiang Xin, Yingtao Guo, Ying Diao, Xianjuan Kou, Lan Luo , Zhimin Yin*. Ampelopsin reduces endotoxic inflammation via repressing ROS-mediated activation of PI3K/Akt/NF-κB signaling pathways. International Immunopharmacology 12 :278–287,2012(*Corresponding author).
  • Jingjing Kang, Yushun Zhang, Xiang Cao, Jie Fan, Guilan Li, Qi Wang, Ying Diao, Zhihui Zhao,Lan Luo, Zhimin Yin* . Lycorine inhibits lipopolysaccharide-induced iNOS and COX-2 up-regulation in RAW264.7 cells through suppressing P38 and STATs activation and increases the survival rate of mice after LPS challenge. International Immunopharmacology,12 249–256,2012(*Corresponding author).
  • Li G, Ye Y, Kang J, Yao X, Zhang Y, Jiang W, Gao M, Dai Y, Xin Y, Wang Q, Yin Z*, Luo L l-Theanine prevents alcoholic liver injury through enhancing the antioxidant capability of hepatocytes. Food Chem Toxicol. 50(2):14.363-372, 2012(*Corresponding author).
  • Guilan Li • Jingjing Kang • Xiangyang Yao •Yinqiang Xin • Qi Wang • Yin Ye • Lan Luo •Zhimin Yin*. The component of green tea, L-theanine protects human hepatic L02 cells from hydrogen peroxide-induced apoptosis. Eur Food Res Technol,233:427–435,2011(*Corresponding author).
  • Yimiao Xu, Yinqiang Xin, Ying Diao, Changyan Lu, Jin Fu, Lan Luo, Zhimin Yin*.Synergistic Effects of Apigenin and Paclitaxel on Apoptosis of Cancer Cells. PLoS ONE. 6(12) e29169,2011(*Corresponding author).
  • Kou X, Qi S, Dai W, Luo L, Yin Z*..Arctigenin inhibits lipopolysaccharide-induced iNOS expression in RAW264.7 cells through suppressing JAK-STAT signal pathway.Int Immunopharmacol. 11(8):1095-102. 2011 (*Corresponding author).
  • Yao X, Zhu F, Zhao Z, Liu C, Luo L, Yin Z*.. Arctigenin enhances chemosensitivity of cancer cells to cisplatin through inhibition of the STAT3 signaling pathway. J Cell Biochem. 112(10):2837-49. 2011(*Corresponding author).
  • Wang Q, Zhu F, Xin Y, Liu J, Luo L, Yin Z*..Expression and purification of antimicrobial peptide buforin IIb in Escherichia coli. Biotechnol Lett. 33(11):2121-6. 2011 (*Corresponding author).
  • Qian J, Jiang F, Wang B, Yu Y, Zhang X, Yin Z, Liu C.Ophiopogonin D prevents H2O2-induced injury in primary human umbilical vein endothelial cells. J Ethnopharmacol. 24;128(2):438-45. 2010 
  • Wang Q, Min C, Zhu F, Xin Y, Zhang S, Luo L, Yin Z*,Production of Bioactive γ-Glutamyl Transpeptidase in Escherichia coli Using SUMO Fusion Partner and Application of the Recombinant Enzyme to L: -Theanine Synthesis. Curr Microbiol. 62:1535–1541,2011(*Corresponding author).
  • Huang H, Pan Y, Ye Y, Gao M, Yin Z*, Luo L. Dipyrithione attenuates oleic acid-induced acute lung injury. Pulm Pharmacol Ther.24(1):74-80. 2011 (*Corresponding author).
  • Ben P, Liu J, Lu C, Xu Y, Xin Y, Fu J, Huang H, Zhang Z, Gao Y, Luo L, Yin Z*.Curcumin promotes degradation of inducible nitric oxide synthase and suppresses its enzyme activity in RAW 264.7 cells.  int Immunopharmacol. 11(2): 179-186,2011(*Corresponding author).
  • Zhang C, Yuan X,Mao W, Yue L,Yin Z*. Inhibition of cadmium-induced apoptosis by glutathione S-transferase P1 via mitogen-activated protein kinases and mitochondrial pathways Environmental Toxicology and Pharmacology,30(2):202-208. 2010(*Corresponding author).
  • Liu J, Hong S, Feng Z, Xin Y, Wang Q, Fu J, Zhang C, Li G, Luo L, Yin Z*. Regulation of lipopolysaccharide-induced inflammatory response by heat shock protein 27 in THP-1 cells.Cell Immunol. 264(2):127–134. 2010(*Corresponding author).
  • Zhang C, Yuan X, Yue L, Fu J, Luo L, Yin Z*. PIASy interacts with p73alpha and regulates cell cycle in HEK293 cells.Cell Immunol.263(2):235-40. 2010(*Corresponding author).
  • Han C, Fu J, Liu Z, Huang H, Luo L, Yin Z*. Dipyrithione inhibits IFN-gamma-induced JAK/STAT1 signaling pathway activation and IP-10/CXCL10 expression in RAW264.7 cells.  Inflamm Res. 59(10):809-16,2010(*Corresponding author).
  • Gao Y, Han C, Huang H, Xin Y, Xu Y, Luo L, Yin Z*. Heat shock protein 70 together with its co-chaperone CHIP inhibits TNF-alpha induced apoptosis by promoting proteasomal degradation of apoptosis signal-regulating kinase1 Apoptosis. 15(7):822-33. 2010. (*Corresponding author).
  • Zhang X, Huang H, Yang T, Ye Y, Shan J, Yin Z*, Luo L. Chlorogenic acid protects mice against lipopolysaccharide-induced acute lung injury  Injury. 41(7):943-9,2010. (*Corresponding author).
  • Ge, Junchao, Feng, Youjun, Ji, Hongfeng, Zhang, Huimin, Zheng, Feng, Wang, Changjun, Yin, Zhimin*, Pan, Xiuzhen, Tang, Jiaqi. Inactivation of Dipeptidyl Peptidase IV Attenuates the Virulence of Streptococcus suis Serotype 2 that Causes Streptococcal Toxic Shock Syndrome. Current Microbiology, 59(3), pp 248-255,  2009. (*Corresponding author).
  • Shan, Jianhua, Fu, Jin, Zhao, Zhihui, Kong, Xiuqin, Huang, Huang, Luo, Lan, Yin, Zhimin*. Chlorogenic acid inhibits lipopolysaccharide-induced cyclooxygenase-2 expression in RAW264.7 cells through suppressing NF-kappa B and JNK/AP-1 activation. International Immunopharmacology, 9(9), pp 1042-1048, 2009. (*Corresponding author).
  • Zhang, Zhengping, Hao, Jiaying, Zhao, Zhihui, Ben, Peiling, Fang, Fang, Shi, Lijun, Gao, Yanhong, Liu, Junhong, Wen, Chuanjun, Luo, Lan, Yin, Zhimin*. beta-Arrestins facilitate ubiquitin-dependent degradation of apoptosis signal-regulating kinase 1 (ASK1) and attenuate H2O2-induced apoptosis. Cellular Signalling, 21(7), pp 1195-1206,  2009. (*Corresponding author)
  • Shi, Lijun, Zhang, Zhengping, Fang, Shuping, Xu, Junfeng, Liu, Junhong, Shen, Jiayin, Fang, Fang, Luo, Lan, Yin, Zhimin*. Heat shock protein 90 (Hsp90) regulates the stability of transforming growth factor beta-activated kinase 1 (TAK1) in interleukin-1 beta-induced cell signaling. Molecular Immunology, 46(4), pp 541-550,  2009. (*Corresponding author).
  • Luo, Lan, Wang, Yu, Feng, Qin, Zhang, Hong, Xue, Bin, Shen, Jiayin, Ye, Yin, Han, Xiaodong, Ma, Hsiaoyen, Xu, Jun, Chen, Dan, Yin, Zhimin*. Recombinant protein glutathione S-transferases P1 attenuates inflammation in mice. Molecular Immunology, 46(5), pp 848-857,  2009. (*Corresponding author).
  • Wu, Yifan, Liu, Junhong, Zhang, Zhengping, Huang, Huang, Shen, Jiayin, Zhang, Shuangquan, Jiang, Yong, Luo, Lan, Yin, Zhimin*. Hsp27 regulates IL-1 stimulated IKK activation through interacting with TRAF6 and affecting its ubiquitination. Cellular Signalling, 21(1), pp 143-150,  2009(*Corresponding author).
  • Chen, Li, Kong, Xiuqin, Fu, Jin, Xu, Yimiao, Fang, Shuping, Hua, Peng, Luo, Lan, Yin, Zhimin*. CHIP facilitates ubiquitination of inducible nitric oxide synthase and promotes its proteasomal degradation. Cellular Immunology, 258(1), pp 38-43,  2009. (*Corresponding author).
  • Fang, Shuping, Fu, Jin, Yuan, Xia, Han, Cui, Shi, Lijun, Xin, Yinqiang, Luo, Lan, Yin, Zhimin*. Heat shock protein 90 regulates the stability of MEKK3 in HEK293 cells. Cellular Immunology, 259(1), pp 49-55,  2009(*Corresponding author).

Books

Springer-Verlag Berlin Heidelberg 2015

M. Schwab (ed.), Encyclopedia of Cancer, DOI 10.1007/978-3-642-27841-9_2441-2

Academic Title

Member of the Chinese Pathological Society

Contact

Tel:+86-025-85891305

E-mail:yinzhimin@njnu.edu.cn