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Research

Jiangsu Key Laboratory for Molecular and Medical Biotechnology


Jiangsu Key Laboratory for Molecular and Medical Biotechnology

Director: Prof. Chang Liu
Secretary: Tingming Liang, PhD

Introduction
     Jiangsu Key Laboratory for Molecular and Medical Biotechnology is approved by the Education Department of Jiangsu Province. It is a professional institution focusing on the pathogenesis of major diseases from the view of basic molecular medicine research and technological development in Jiangsu Province. The laboratory consists of Institute of Molecular Cell Biology and Institute of Biochemical and Biological Products in College of Life Sciences. The faculty team of the laboratory now has 33 full-time researchers, including 14 professors, 11 associate professors, 6 lecturers and 2 technicians. Among them, 29 faculties hold a PhD degree. Some of the faculties have been awarded with high-level honors, such as Ten Thousand Talents Program, Distinguished Professor of Jiangsu Province, etc. In 2014, lab members were in charge of 57 research projects (23 national projects). Representative projects include Outstanding Youth Foundation from NCSF, the National Basic Research Program of China (973 Program), Distinguished Young Scholars of Jiangsu Province. The total budget exceeds 30 million Yuan. Lab members had published 85 papers in scientific journals indexed by SCI from 2011 to 2013 as the 1st or corresponding authors. Representative papers were published in Molecular Cell, Hepatology, etc. In addition, 18 invention patents were authorized to the lab members.

Research Interests

    Molecular pathology of metabolic diseases/cardiovascular diseases: Integration of the circadian clock and energy metabolism, Cardiac ion channel structure and its regulation;
DNA damage repair and tumorigenesis: Antibody engineering and the development and application of therapeutic antibodies, Cell stress and signal transduction, The mechanism of tumor-related gene functions;
Inflammation and cell stress: Signal transduction of glutathione glycosides peptide S-transferase, heat shock protein and JNK in the inflammatory response, the role of glutathione glycosides peptide S-transferase, heat shock protein and JNK in the process of cellular stress.


Major Achievements in Recent Five Years

  1. Guo Z, Kanjanapangka J, Liu N, et al. Sequential Posttranslational Modifications Program FEN1 Degradation during Cell-Cycle Progression. Molecular Cell, 2012, 47(3):444-56. (IF=14.18)
  2. Tao W, Chen S, Shi G, et al. SWItch/sucrose nonfermentable (SWI/SNF) complex subunit BAF60a integrates hepatic circadian clock and energy metabolism. Hepatology, 2011, 54(4):1410-1420. (IF=11.65)
  3. Siyu Chen, Wenxiang Zhang, Chunqi Tang, et al. Vanin-1 Is a Key Activator for Hepatic Gluconeogenesis. Diabetes, 2014, 63(6):2073-2085. (IF=7.59)
  4. Siyu C, Yan D, Zhao Z, et al. Hyperlipidaemia impairs the circadian clock and physiological homeostasis of vascular smooth muscle cells via the suppression of Smarcd1.[J]. Journal of Pathology, 2014, 233(2):159–169.
  5. Long Chen, Xu B, Lei L, et al. Cadmium induction of reactive oxygen species activates the mTOR pathway, leading to neuronal cell death [J]. Free Radical Biology & Medicine, 2011, 50(5):624-32. (IF=5.71)
  6. Ning S, Yue S, Shan-Shan L, et al. GGPPS, a new EGR-1 target gene, reactivates ERK 1/2 signaling through increasing Ras prenylation.[J]. American Journal of Pathology, 2011, 179(6):2740–2750. (IF=5.22)
  7. Outstanding Youth Foundation of NCSF, 2014, Chang Liu;
  8. The National Basic Research Program of China (973 Program; 2013CB911600), 2013, Zhigang Guo;
  9. Ten Thousand Talents Program, 2013, Chang Liu;
  10. Distinguished Young Scholars of Jiangsu Province, Chang Liu (2014), Zhigang Guo (2013).