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New Progress In The Formation Mechanism Of Fatty Liver In Takifugu fasciatus By The Research Team Of Prof. Yin Shaowu

Recently, research group of the Prof. Yin Shaowu has made the new progress in the formation mechanism of fatty liver in Takifugu fasciatus, as the title of “Copper nanoparticles induce the formation of fatty liver in Takifugu fasciatus triggered by the PERK-EIF2α- SREBP-1c pathway”, published in NanoImpact (SCI 1 area, if = 5.47).


Takifugu fasciatus is a species of marine freshwater breeding migratory fish. It is widespread in the East China Sea, the South China Sea, the Sea of Japan, and inland waters in China and Korea. In recent years, as a delicacy and commercially farmed puffer fish, the area for aquatic breeding of T. fasciatus has gradually expanded. Based on the 2017 data from puffer fish branch of the China Fisheries Association, the yearly output value is more than CNY 10 billion. The annual consumption of T. fasciatus is approximately 10,000 tons in Korea. In Japan, T. fasciatus is considered to have a large value-added space. However, the currently cultured T. fasciatus generally suffer from fatty liver disease, which seriously affects the healthy development of T. fasciatus and negatively impacts on the breeding industry. 
For the first time, the research team finds that exposure to Copper nanoparticles (CuNPs) induces fatty liver formation in T. fasciatus,  triggered by the PERK-EIF2α pathway by activating the SREBP-1c pathway to promote fatty liver formation.

In addition, the research group published another review article recently in Reviews in Fisheries Science & Aquaculture, as the title of “Responses to environmental stress and its mitigation in Takifugu fasciatus